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Gene

TCF7L2

transcription factor 7 like 2

Summary

Cytogenetic location
10q25.2-q25.3
Coordinates
Chromosome 10: 112,950,247–113,167,678 (GRCh38)
Exons
15 exons across 217.4 kb
Protein
619 amino acids
Also known as
TCF-4
Previous symbols
TCF4
MANE Select transcript
ENST00000355995.9NM_001367943.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TCF7L2 yet. The test sequences your whole genome, so your data includes it all the same.

How TCF7L2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where TCF7L2 sits. TCF7L2 and 2 genes near it on chromosome 10, from 112,558,963 to 113,558,962.Chromosome 1010q25.2-q25.3p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.3112.6 Mb112.8 Mb113 Mb113.2 Mb113.4 MbVTI1A: 112,446,998–112,818,897, forward strandVTI1ATCF7L2: 112,950,247–113,167,678, forward strandTCF7L2HABP2: 113,550,837–113,592,878, forward strandHABP2Diagram of TCF7L2: 15 exons on the forward strand of chromosome 10Exon 11: 1 known disease-causing siteExon 1: 112,950,247–112,950,945, 699 basesExon 2: 112,951,207–112,951,273, 67 basesExon 3: 112,951,483–112,951,607, 125 basesExon 4: 112,964,556–112,964,624, 69 basesExon 5: 113,040,025–113,040,126, 102 basesExon 6: 113,141,184–113,141,316, 133 basesExon 7: 113,143,923–113,144,025, 103 basesExon 8: 113,146,011–113,146,097, 87 basesExon 9: 113,150,998–113,151,123, 126 basesExon 10: 113,151,725–113,151,884, 160 basesExon 11: 113,152,333–113,152,440, 108 basesExon 12: 113,158,021–113,158,069, 49 basesExon 13: 113,158,667–113,158,717, 51 basesExon 14: 113,159,920–113,159,992, 73 basesExon 15: 113,165,555–113,167,678, 2,124 bases1510155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.1 kb of the gene's 217.4 kb; 1,860 of those bases code for the protein.

How a genome test reads TCF7L2

2

positions in TCF7L2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 217.4 kb of TCF7L2, introns included, not only the 4.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TCF7L2 gene: transcription factor 7 like 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/tcf7l2

Vancouver

Dante Labs. TCF7L2 gene: transcription factor 7 like 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tcf7l2

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