Traits

Traits linked to MOGS

mannosyl-oligosaccharide glucosidase

The Human Phenotype Ontology links 57 traits to MOGS, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
High palate	Always
Long eyelashes	Always
Prominent back of the head	Always
Receding chin	Always
Short opening between the eyelids	Always
Wide nose	Always
Abnormal facial shape	Often (30–79%)
Narrow opening between the eyelids	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Demyelinating peripheral neuropathy	Always
EEG with burst suppression	Always
Epilepsy	Always
Absent brainstem auditory responses	Sometimes (5–29%)
Dystonia	Sometimes (5–29%)
Underdevelopment of part of brain called corpus callosum	Sometimes (5–29%)
Degeneration of cerebrum	Not recorded
Global developmental delay	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Always
Thoracic scoliosis	Always
Decreased muscle tone in infant	Often (30–79%)
Bone fracture	Sometimes (5–29%)
Low muscle tone	Not recorded
Recurrent fractures	Not recorded

Laboratory abnormality

Trait	How often it is seen
Elevated circulating aspartate aminotransferase concentration	Always
Generalized edema	Always
Reduced tissue mannosyl-oligosaccharide glucosidase activity	Always
Excess fluid in lungs	Sometimes (5–29%)
Fluid retention	Sometimes (5–29%)

Abnormal cellular phenotype

Trait	How often it is seen
Decreased circulating IgA concentration	Always
Decreased circulating antibody level	Often (30–79%)
Decreased circulating IgM concentration	Often (30–79%)
Decreased circulating IgG concentration	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
An opening in the wall separating the top two chambers of the heart	Sometimes (5–29%)
Enlarged heart	Sometimes (5–29%)
Enlarged liver and spleen	Sometimes (5–29%)
Left ventricular hypertrophy	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Always
Chronic constipation	Sometimes (5–29%)
Nasogastric tube feeding	Sometimes (5–29%)
Feeding difficulties in infancy	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Underdeveloped female external genitalia	Always
Underdevelopment of external reproductive organs	Often (30–79%)
Hydrocele testis	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Excessive hairiness	Often (30–79%)
Fair hair	Sometimes (5–29%)
Hair loss	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Apnea	Sometimes (5–29%)
Breathing difficulties	Sometimes (5–29%)
Slow breathing	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Hand clenching	Always
Overlapping fingers	Always

Abnormality of the endocrine system

Trait	How often it is seen
Inappropriate antidiuretic hormone secretion	Sometimes (5–29%)
Underactive thyroid	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Abnormality of visual evoked potentials	Sometimes (5–29%)
Optic atrophy	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low platelet count	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
High levels of amniotic fluid	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MOGS and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test