Traits

Traits linked to LPIN2

lipin 2

The Human Phenotype Ontology links 44 traits to LPIN2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Erythroid hyperplasia	Always
Bone marrow disease	Very often (80–99%)
Congenital hypoplastic anemia	Very often (80–99%)
Hypochromic microcytic anemia	Very often (80–99%)
Elevated white blood count	Often (30–79%)
Microcytic anemia	Often (30–79%)
Anemia of inadequate production	Not recorded
Decreased mean corpuscular volume	Not recorded

Laboratory abnormality

Trait	How often it is seen
Episodic fever	Always
High ESR	Always
Joint swelling	Always
Fever	Very often (80–99%)
Fluid retention	Often (30–79%)
High urine protein levels	Sometimes (5–29%)
Small amount of blood in urine	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Abnormal inflammatory response	Very often (80–99%)
Bone infection	Very often (80–99%)
Pimple	Very often (80–99%)
Acne	Often (30–79%)
Skin rash	Often (30–79%)
Inflammatory abnormality of the skin	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Bone pain	Always
Delayed bone maturation	Always
Increased bone mineral density	Often (30–79%)
Synovitis	Often (30–79%)
Flexed joint that cannot be straightened	Sometimes (5–29%)
Increased susceptibility to fractures	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Always
Wasting syndrome	Very often (80–99%)
Weight loss	Very often (80–99%)
Growth delay	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Enlarged liver and spleen	Very often (80–99%)
Increased spleen size	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Often (30–79%)
Malabsorption	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Cough	Sometimes (5–29%)
Lung infiltrates	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Joint pain	Always
Muscle ache	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Irregular wide portion of a long bone	Very often (80–99%)

Abnormality of the endocrine system

Trait	How often it is seen
Delayed puberty	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Glomerulopathy	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Papule	Very often (80–99%)

Abnormality of the nervous system

Trait	How often it is seen
Headache	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to LPIN2 and how often each is seen. Find out more at hpo.jax.org.

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