Traits

Traits linked to GPR35

G protein-coupled receptor 35

The Human Phenotype Ontology links 55 traits to GPR35, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Abnormal biliary tract morphology	Very often (80–99%)
Slowed or blocked flow of bile from liver	Very often (80–99%)
Abnormal large intestine physiology	Often (30–79%)
Accumulation of fluid in the abdomen	Often (30–79%)
Enlarged liver	Often (30–79%)
Hepatic fibrosis	Often (30–79%)
Scar tissue replaces healthy tissue in the liver	Often (30–79%)
Ulcerative colitis	Often (30–79%)
Abdominal pain	Sometimes (5–29%)
Adenocarcinoma of the large intestine	Sometimes (5–29%)
Bile duct cancer	Sometimes (5–29%)
Celiac disease	Sometimes (5–29%)
Chronic liver failure	Sometimes (5–29%)
Gallstones	Sometimes (5–29%)
Hepatocellular carcinoma	Sometimes (5–29%)
Jaundice	Sometimes (5–29%)
Liver inflammation	Sometimes (5–29%)
Pancreatic inflammation	Sometimes (5–29%)
Acute liver failure	Rarely (1–4%)
Neoplasm of the gallbladder	Rarely (1–4%)

Laboratory abnormality

Trait	How often it is seen
Elevated alkaline phosphatase of hepatic origin	Often (30–79%)
Fever	Often (30–79%)
High liver enzymes	Often (30–79%)
Decreased circulating vitamin K concentration	Sometimes (5–29%)
Deficient in vitamin D	Sometimes (5–29%)
Fluid around lungs	Sometimes (5–29%)
Low albumin	Sometimes (5–29%)
Type 1 diabetes	Sometimes (5–29%)
Vitamin A deficiency	Sometimes (5–29%)
Vitamin E deficiency	Sometimes (5–29%)
Amyloid deposition	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Dilated superficial abdominal veins	Often (30–79%)
Enlarged liver and spleen	Often (30–79%)
Increased spleen size	Often (30–79%)
Portal hypertension	Often (30–79%)
Spider hemangioma	Often (30–79%)
Cardiac failure	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Prolonged prothrombin time	Sometimes (5–29%)
Abnormal eosinophil morphology	Not recorded
Histiocytosis	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Diffuse skeletal muscle wasting	Sometimes (5–29%)
Osteopenia	Sometimes (5–29%)
Osteoporosis	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Autoimmunity	Very often (80–99%)
Recurrent systemic pyogenic infections	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Depression	Sometimes (5–29%)
Encephalopathy	Rarely (1–4%)

Abnormal cellular phenotype

Trait	How often it is seen
Polyclonal elevation of circulating IgM concentration	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Palmar telangiectasia	Often (30–79%)

Abnormality of the endocrine system

Trait	How often it is seen
Thyroid gland inflammation	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Uveitis	Rarely (1–4%)

Abnormality of the genitourinary system

Trait	How often it is seen
Renal failure	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Itching	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Weight loss	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to GPR35 and how often each is seen. Find out more at hpo.jax.org.

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