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Traits

Traits linked to GPR35

G protein-coupled receptor 35

The Human Phenotype Ontology links 55 traits to GPR35, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

TraitHvor ofte det ses
Abnormal biliary tract morphologyMeget ofte (80–99 %)
Slowed or blocked flow of bile from liverMeget ofte (80–99 %)
Abnormal large intestine physiologyOfte (30–79 %)
Accumulation of fluid in the abdomenOfte (30–79 %)
Enlarged liverOfte (30–79 %)
Hepatic fibrosisOfte (30–79 %)
Scar tissue replaces healthy tissue in the liverOfte (30–79 %)
Ulcerative colitisOfte (30–79 %)
Abdominal painNogle gange (5–29 %)
Adenocarcinoma of the large intestineNogle gange (5–29 %)
Bile duct cancerNogle gange (5–29 %)
Celiac diseaseNogle gange (5–29 %)
Chronic liver failureNogle gange (5–29 %)
GallstonesNogle gange (5–29 %)
Hepatocellular carcinomaNogle gange (5–29 %)
JaundiceNogle gange (5–29 %)
Liver inflammationNogle gange (5–29 %)
Pancreatic inflammationNogle gange (5–29 %)
Acute liver failureSjældent (1–4%)
Neoplasm of the gallbladderSjældent (1–4%)

Laboratory abnormality

TraitHvor ofte det ses
Elevated alkaline phosphatase of hepatic originOfte (30–79 %)
FeverOfte (30–79 %)
High liver enzymesOfte (30–79 %)
Decreased circulating vitamin K concentrationNogle gange (5–29 %)
Deficient in vitamin DNogle gange (5–29 %)
Fluid around lungsNogle gange (5–29 %)
Low albuminNogle gange (5–29 %)
Type 1 diabetesNogle gange (5–29 %)
Vitamin A deficiencyNogle gange (5–29 %)
Vitamin E deficiencyNogle gange (5–29 %)
Amyloid depositionIkke registreret

Abnormality of the cardiovascular system

TraitHvor ofte det ses
Dilated superficial abdominal veinsOfte (30–79 %)
Enlarged liver and spleenOfte (30–79 %)
Increased spleen sizeOfte (30–79 %)
Portal hypertensionOfte (30–79 %)
Spider hemangiomaOfte (30–79 %)
Cardiac failureNogle gange (5–29 %)

Abnormality of blood and blood-forming tissues

TraitHvor ofte det ses
Prolonged prothrombin timeNogle gange (5–29 %)
Abnormal eosinophil morphologyIkke registreret
HistiocytosisIkke registreret

Abnormality of the musculoskeletal system

TraitHvor ofte det ses
Diffuse skeletal muscle wastingNogle gange (5–29 %)
OsteopeniaNogle gange (5–29 %)
OsteoporosisNogle gange (5–29 %)

Abnormality of the immune system

TraitHvor ofte det ses
AutoimmunityMeget ofte (80–99 %)
Recurrent systemic pyogenic infectionsIkke registreret

Abnormality of the nervous system

TraitHvor ofte det ses
DepressionNogle gange (5–29 %)
EncephalopathySjældent (1–4%)

Abnormal cellular phenotype

TraitHvor ofte det ses
Polyclonal elevation of circulating IgM concentrationNogle gange (5–29 %)

Abnormality of limbs

TraitHvor ofte det ses
Palmar telangiectasiaOfte (30–79 %)

Abnormality of the endocrine system

TraitHvor ofte det ses
Thyroid gland inflammationNogle gange (5–29 %)

Abnormality of the eye

TraitHvor ofte det ses
UveitisSjældent (1–4%)

Abnormality of the genitourinary system

TraitHvor ofte det ses
Renal failureNogle gange (5–29 %)

Abnormality of the integument

TraitHvor ofte det ses
ItchingNogle gange (5–29 %)

Constitutional symptom

TraitHvor ofte det ses
FatigueNogle gange (5–29 %)

Growth abnormality

TraitHvor ofte det ses
Weight lossOfte (30–79 %)

Hvor hyppigt det ses hos personer med en af genets tilstande, den hyppigste værdi på tværs af dem, sådan som Human Phenotype Ontology registrerer det. Disse sider beskriver egenskaber og den forskning, der ligger bag dem. De er ikke en diagnose, og hvis du har spørgsmål om symptomer, bør du spørge en læge eller genetisk rådgiver.

Hvor oplysningerne kommer fra

  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to GPR35 and how often each is seen. Find out more at hpo.jax.org.

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