Trait

Spider hemangioma

A form of telangiectasis characterized by a central elevated red dot the size of a pinhead, representing an arteriole, with numerous small blood vessels that radiate out thereby resembling the legs of a spider. Characteristically, compression of the central arteriole causes the entire lesion to blanch, and the lesion quickly refills once the compression is released.

HPO HP:0012522

Body system: Abnormality of the cardiovascular system Abnormality of the integument

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5 genes linked to Spider hemangioma

Changes in these genes cause rare conditions in which Spider hemangioma is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
GPR35G protein-coupled receptor 35	Often (30–79%)	In 1 condition
MST1macrophage stimulating 1	Often (30–79%)	In 1 condition
SEMA4Dsemaphorin 4D	Often (30–79%)	In 1 condition
TCF4transcription factor 4	Often (30–79%)	In 1 condition
SLC37A4solute carrier family 37 member 4	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Telangiectasia of the skin

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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