Trait
Ulcerative colitis
A chronic inflammatory bowel disease that includes characteristic ulcers, or open sores, in the colon. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset and intermittent periods of exacerbated symptoms contrasting with periods that are relatively symptom-free. In contrast to Crohn's disease this special form of colitis begins in the distal parts of the rectum, spreads continually upwards and affects only mucose and submucose tissue of the colon.
Summary
- Also called
- Colitis ulcerosa
Reference genomeGRCh38hg38
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Get my Genome Test17 genes linked to Ulcerative colitis
Changes in these genes cause rare conditions in which Ulcerative colitis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| IL37interleukin 37 | Always | In 1 condition |
| MASP2MBL associated serine protease 2 | Always | In 1 condition |
| BACH2BACH transcriptional regulator 2 | Often (30–79%) | In 1 condition |
| GPR35G protein-coupled receptor 35 | Often (30–79%) | In 1 condition |
| MST1macrophage stimulating 1 | Often (30–79%) | In 1 condition |
| PLCG2phospholipase C gamma 2 | Often (30–79%) | In 1 condition |
| SEMA4Dsemaphorin 4D | Often (30–79%) | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Often (30–79%) | In 1 condition |
| TCF4transcription factor 4 | Often (30–79%) | In 1 condition |
| CARD11caspase recruitment domain family member 11 | Sometimes (5–29%) | In 1 condition |
| CYBC1cytochrome b-245 chaperone 1 | Sometimes (5–29%) | In 1 condition |
| DOCK11dedicator of cytokinesis 11 | Sometimes (5–29%) | In 1 condition |
| MAP3K7mitogen-activated protein kinase kinase kinase 7 | Sometimes (5–29%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Sometimes (5–29%) | In 1 condition |
| IL6interleukin 6 | Not recorded | In 1 condition |
| INAVAinnate immunity activator | Not recorded | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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