Traits

Traits linked to FGF3

fibroblast growth factor 3

The Human Phenotype Ontology links 54 traits to FGF3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Decreased size of tooth	Always
Widely spaced teeth	Always
Abnormal dental pulp morphology	Very often (80–99%)
Abnormal shape of molar tooth	Very often (80–99%)
Abnormality of canine	Very often (80–99%)
Cone shaped tooth	Very often (80–99%)
Dental cavities	Very often (80–99%)
Abnormal tooth enamel	Often (30–79%)
Abnormality of the upper jaw bone	Often (30–79%)
Absence of premolar	Often (30–79%)
Delayed eruption of teeth	Often (30–79%)
Downward slanting of the opening between the eyelids	Often (30–79%)
Full cheeks	Often (30–79%)
Gum disease	Often (30–79%)
Gum enlargement	Often (30–79%)
Jugular foramen stenosis	Often (30–79%)
Little lower jaw	Often (30–79%)
Long face	Often (30–79%)
Long philtrum	Often (30–79%)
Nasal tip, upturned	Often (30–79%)
Pointed chin	Often (30–79%)
Prominent nose	Often (30–79%)
Pulp stones	Often (30–79%)
Taurodontia	Often (30–79%)
Underdeveloped tissue around nostril	Often (30–79%)
Wide nasal bridge	Often (30–79%)
Extra teeth	Sometimes (5–29%)
Failure of development of between one and six teeth	Sometimes (5–29%)
Monobrow	Sometimes (5–29%)
Odontoma	Sometimes (5–29%)
Peg-shaped maxillary lateral incisors	Not recorded

Abnormality of the ear

Trait	How often it is seen
Absent inner ear	Always
Microtia, first degree	Always
Profound sensorineural hearing impairment	Always
Anteverted ears	Very often (80–99%)
Hearing impairment	Very often (80–99%)
Progressive sensorineural hearing impairment	Very often (80–99%)
Sensorineural hearing impairment	Very often (80–99%)
Small ears	Very often (80–99%)
High-frequency sensorineural hearing impairment	Often (30–79%)
Fluid behind eardrum	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Abnormally small eyeball	Sometimes (5–29%)
Cat eye	Sometimes (5–29%)
Clouding of the lens of the eye	Sometimes (5–29%)
Cornea of eye less than 10mm in diameter	Sometimes (5–29%)
Cross-eyed	Sometimes (5–29%)
Hole in the back of the eye	Sometimes (5–29%)
Lens coloboma	Sometimes (5–29%)
Severe farsightedness	Sometimes (5–29%)
Wide-set eyes	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Delayed motor skills	Always
Abnormal cranial nerve morphology	Very often (80–99%)

Abnormality of the integument

Trait	How often it is seen
Skin tags	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Tall stature	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FGF3 and how often each is seen. Find out more at hpo.jax.org.

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