Trait
Reduced factor VII activity
Reduced activity of coagulation factor VII. Factor VII is part of the extrinsic coagulation pathway, which is initiated at the site of injury in response to the release of tissue factor (fIII). Tissue factor and activated factor VII catalyze the activation of factor X.
Summary
Reference genomeGRCh38hg38
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Get my Genome Test5 genes linked to Reduced factor VII activity
Changes in these genes cause rare conditions in which Reduced factor VII activity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| F7coagulation factor VII | Always | In 1 condition |
| GGCXgamma-glutamyl carboxylase | Always | In 3 conditions |
| SLC37A4solute carrier family 37 member 4 | Always | In 1 condition |
| AHCYadenosylhomocysteinase | Often (30–79%) | In 1 condition |
| VKORC1vitamin K epoxide reductase complex subunit 1 | Often (30–79%) | In 2 conditions |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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