{
  "url": "https://dantelabs.com/genes/f7",
  "gene": {
    "slug": "f7",
    "symbol": "F7",
    "name": "coagulation factor VII",
    "hgnc": "HGNC:3544",
    "summary": null,
    "location": "13q34",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [],
    "ensemblId": "ENSG00000057593",
    "entrezId": 2155,
    "omim": [
      "613878"
    ],
    "uniprot": [
      "P08709"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "13",
      "start": 113105791,
      "end": 113120685,
      "strand": "+",
      "ensemblTranscript": "ENST00000346342.8",
      "refseqTranscript": "NM_019616.4",
      "ensemblProtein": "ENSP00000329546.4",
      "refseqProtein": "NP_062562.1",
      "exons": [
        {
          "start": 113105791,
          "end": 113105905
        },
        {
          "start": 113110690,
          "end": 113110850
        },
        {
          "start": 113113752,
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        },
        {
          "start": 113113847,
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        },
        {
          "start": 113115660,
          "end": 113115800
        },
        {
          "start": 113116766,
          "end": 113116875
        },
        {
          "start": 113117473,
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        },
        {
          "start": 113118413,
          "end": 113120685
        }
      ],
      "cds": {
        "start": 113105842,
        "end": 113119008
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "13",
      "start": 113760105,
      "end": 113774995,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 112613238,
      "end": 113613237,
      "genes": [
        {
          "symbol": "ATP11A",
          "ensemblId": "ENSG00000068650",
          "biotype": "protein_coding",
          "start": 112689911,
          "end": 112887177,
          "strand": "+",
          "slug": "atp11a"
        },
        {
          "symbol": "MCF2L",
          "ensemblId": "ENSG00000126217",
          "biotype": "protein_coding",
          "start": 112894330,
          "end": 113100412,
          "strand": "+",
          "slug": "mcf2l"
        },
        {
          "symbol": "F10",
          "ensemblId": "ENSG00000126218",
          "biotype": "protein_coding",
          "start": 113122771,
          "end": 113149531,
          "strand": "+",
          "slug": "f10"
        },
        {
          "symbol": "PROZ",
          "ensemblId": "ENSG00000126231",
          "biotype": "protein_coding",
          "start": 113158388,
          "end": 113173625,
          "strand": "+",
          "slug": "proz"
        },
        {
          "symbol": "PCID2",
          "ensemblId": "ENSG00000126226",
          "biotype": "protein_coding",
          "start": 113177117,
          "end": 113209458,
          "strand": "-",
          "slug": "pcid2"
        },
        {
          "symbol": "CUL4A",
          "ensemblId": "ENSG00000139842",
          "biotype": "protein_coding",
          "start": 113208193,
          "end": 113267108,
          "strand": "+",
          "slug": "cul4a"
        },
        {
          "symbol": "LAMP1",
          "ensemblId": "ENSG00000185896",
          "biotype": "protein_coding",
          "start": 113297088,
          "end": 113324413,
          "strand": "+",
          "slug": "lamp1"
        },
        {
          "symbol": "GRTP1",
          "ensemblId": "ENSG00000139835",
          "biotype": "protein_coding",
          "start": 113320007,
          "end": 113364165,
          "strand": "-",
          "slug": "grtp1"
        },
        {
          "symbol": "ADPRHL1",
          "ensemblId": "ENSG00000153531",
          "biotype": "protein_coding",
          "start": 113399611,
          "end": 113453914,
          "strand": "-",
          "slug": "adprhl1"
        },
        {
          "symbol": "DCUN1D2",
          "ensemblId": "ENSG00000150401",
          "biotype": "protein_coding",
          "start": 113455289,
          "end": 113490984,
          "strand": "-",
          "slug": "dcun1d2"
        },
        {
          "symbol": "SLC9D1",
          "ensemblId": "ENSG00000150403",
          "biotype": "protein_coding",
          "start": 113490719,
          "end": 113554590,
          "strand": "+",
          "slug": "slc9d1"
        },
        {
          "symbol": "TFDP1",
          "ensemblId": "ENSG00000198176",
          "biotype": "protein_coding",
          "start": 113584525,
          "end": 113641509,
          "strand": "+",
          "slug": "tfdp1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "rare-inherited-coagulation-factor-deficiencies",
        "name": "Rare Inherited Coagulation Factor Deficiencies",
        "diseases": [
          {
            "mondoId": "MONDO:0002244",
            "name": "Factor VII Deficiency",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "A deficiency of clotting factor VII, mainly caused by changes in F7; bleeding severity varies widely and does not always match factor levels.",
            "management": "Results help plan treatment, such as recombinant factor VIIa, for surgery and childbirth.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "Laboratory for Molecular Medicine",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ],
              "actionability": 10
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0015722",
            "name": "Congenital Vitamin K-Dependent Coagulation Factor Deficiencies",
            "genes": 5,
            "inheritance": "autosomal-recessive",
            "description": "Inherited deficiencies of prothrombin (factor II), factor VII or factor X, or of all vitamin K-dependent factors together (caused by changes in GGCX or VKORC1), which can cause nosebleeds, easy bruising and bleeding after injury, surgery or childbirth.",
            "management": "Knowing in advance allows factor replacement to be planned around surgery and childbirth; the combined form often responds to vitamin K.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Labcorp Genetics (formerly Invitae)",
                "Laboratory for Molecular Medicine",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ],
              "actionability": 10
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/conditions/rare-inherited-coagulation-factor-deficiencies"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "menorrhagia",
        "name": "Abnormally heavy bleeding during menstruation",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/menorrhagia"
      },
      {
        "slug": "gingival-bleeding",
        "name": "Bleeding gums",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/gingival-bleeding"
      },
      {
        "slug": "post-partum-hemorrhage",
        "name": "Bleeding post-delivery",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/post-partum-hemorrhage"
      },
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      },
      {
        "slug": "joint-hemorrhage",
        "name": "Bleeding within a joint",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/joint-hemorrhage"
      },
      {
        "slug": "intracranial-hemorrhage",
        "name": "Bleeding within the skull",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/intracranial-hemorrhage"
      },
      {
        "slug": "epistaxis",
        "name": "Bloody nose",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/epistaxis"
      },
      {
        "slug": "bruising-susceptibility",
        "name": "Bruising susceptibility",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bruising-susceptibility"
      },
      {
        "slug": "gastrointestinal-hemorrhage",
        "name": "Gastrointestinal bleeding",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/gastrointestinal-hemorrhage"
      },
      {
        "slug": "intramuscular-hematoma",
        "name": "Intramuscular hematoma",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/intramuscular-hematoma"
      },
      {
        "slug": "ovarian-cyst",
        "name": "Ovarian cyst",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ovarian-cyst"
      },
      {
        "slug": "prolonged-bleeding-after-dental-extraction",
        "name": "Prolonged bleeding after dental extraction",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/prolonged-bleeding-after-dental-extraction"
      },
      {
        "slug": "prolonged-bleeding-after-surgery",
        "name": "Prolonged bleeding after surgery",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/prolonged-bleeding-after-surgery"
      },
      {
        "slug": "prolonged-prothrombin-time",
        "name": "Prolonged prothrombin time",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/prolonged-prothrombin-time"
      },
      {
        "slug": "reduced-factor-vii-activity",
        "name": "Reduced factor VII activity",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/reduced-factor-vii-activity"
      },
      {
        "slug": "abnormality-of-the-umbilical-cord",
        "name": "Umbilical cord issue",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-umbilical-cord"
      }
    ],
    "related": [
      {
        "slug": "f10",
        "symbol": "F10",
        "name": "coagulation factor X",
        "shared": 1,
        "url": "https://dantelabs.com/genes/f10"
      },
      {
        "slug": "f2",
        "symbol": "F2",
        "name": "coagulation factor II, thrombin",
        "shared": 1,
        "url": "https://dantelabs.com/genes/f2"
      },
      {
        "slug": "ggcx",
        "symbol": "GGCX",
        "name": "gamma-glutamyl carboxylase",
        "shared": 1,
        "url": "https://dantelabs.com/genes/ggcx"
      },
      {
        "slug": "vkorc1",
        "symbol": "VKORC1",
        "name": "vitamin K epoxide reductase complex subunit 1",
        "shared": 1,
        "url": "https://dantelabs.com/genes/vkorc1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}