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Gene

AFP

alpha fetoprotein

Summary

Cytogenetic location
4q13.3
Coordinates
Chromosome 4: 73,436,221–73,456,174 (GRCh38)
Exons
15 exons across 20 kb
Protein
609 amino acids
Also known as
FETA
Previous symbols
HPAFP
MANE Select transcript
ENST00000395792.7NM_001134.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads AFP yet. The test sequences your whole genome, so your data includes it all the same.

How AFP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 4, with a bracket where AFP sits. AFP and 9 genes near it on chromosome 4, from 72,946,198 to 73,946,197.Chromosome 44q13.3p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.273 Mb73.2 Mb73.4 Mb73.6 Mb73.8 MbCOX18: 73,052,362–73,069,755, reverse strandCOX18ANKRD17: 73,073,376–73,259,169, reverse strandANKRD17ALB: 73,397,114–73,426,607, forward strandALBAFP: 73,436,221–73,456,174, forward strandAFPAFM: 73,481,659–73,504,173, forward strandAFMRASSF6: 73,571,550–73,620,631, reverse strandRASSF6CXCL8: 73,740,519–73,747,379, forward strandCXCL8CXCL6: 73,836,622–73,849,064, forward strandCXCL6PF4V1: 73,853,292–73,854,483, forward strandPF4V1CXCL1: 73,868,963–73,871,388, forward strandCXCL1Diagram of AFP: 15 exons on the forward strand of chromosome 4Exon 1: 73,436,221–73,436,347, 127 basesExon 2: 73,437,160–73,437,211, 52 basesExon 3: 73,438,174–73,438,306, 133 basesExon 4: 73,440,602–73,440,813, 212 basesExon 5: 73,442,296–73,442,428, 133 basesExon 6: 73,443,347–73,443,444, 98 basesExon 7: 73,444,993–73,445,122, 130 basesExon 8: 73,447,462–73,447,676, 215 basesExon 9: 73,449,335–73,449,467, 133 basesExon 10: 73,450,036–73,450,133, 98 basesExon 11: 73,450,615–73,450,753, 139 basesExon 12: 73,452,401–73,452,624, 224 basesExon 13: 73,453,765–73,453,897, 133 basesExon 14: 73,455,236–73,455,290, 55 basesExon 15: 73,455,631–73,456,174, 544 bases1234567891011121314155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 20 kb; 1,830 of those bases code for the protein.

Traits linked to AFP

The Human Phenotype Ontology lists these as features of the rare conditions AFP can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). AFP gene: alpha fetoprotein. Retrieved 17 October 2026, from https://dantelabs.com/genes/afp

Vancouver

Dante Labs. AFP gene: alpha fetoprotein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/afp

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