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Gene

KMT2E

lysine methyltransferase 2E (inactive)

Summary

Cytogenetic location
7q22.3
Coordinates
Chromosome 7: 105,014,205–105,115,019 (GRCh38)
Exons
27 exons across 100.8 kb
Protein
1,858 amino acids
Also known as
HDCMC04P, SETD5B
Previous symbols
MLL5
MANE Select transcript
ENST00000311117.8NM_182931.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads KMT2E yet. The test sequences your whole genome, so your data includes it all the same.

How KMT2E is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where KMT2E sits. KMT2E and 6 genes near it on chromosome 7, from 104,564,612 to 105,564,611.Chromosome 77q22.3p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3104.6 Mb104.8 Mb105 Mb105.2 Mb105.4 MbLHFPL3: 104,328,603–104,908,561, forward strandLHFPL3KMT2E: 105,014,205–105,115,019, forward strandKMT2E: 105,040,848–105,040,925, forward strand: 105,040,858–105,040,956, forward strandSRPK2: 105,110,704–105,399,308, reverse strandSRPK2PUS7: 105,439,661–105,522,272, reverse strandPUS7RINT1: 105,532,116–105,569,207, forward strandRINT1Diagram of KMT2E: 27 exons on the forward strand of chromosome 7Exon 3: 2 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 10: 2 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 12: 2 known disease-causing sitesExon 14: 4 known disease-causing sitesExon 15: 3 known disease-causing sitesExon 16: 4 known disease-causing sitesExon 17: 5 known disease-causing sitesExon 18: 2 known disease-causing sitesExon 19: 1 known disease-causing siteExon 20: 2 known disease-causing sitesExon 21: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 23: 6 known disease-causing sitesExon 24: 2 known disease-causing sitesExon 25: 3 known disease-causing sitesExon 26: 1 known disease-causing siteExon 27: 7 known disease-causing sitesExon 1: 105,014,205–105,014,535, 331 basesExon 2: 105,038,126–105,038,199, 74 basesExon 3: 105,040,839–105,041,023, 185 basesExon 4: 105,062,164–105,062,278, 115 basesExon 5: 105,063,351–105,063,580, 230 basesExon 6: 105,066,727–105,066,807, 81 basesExon 7: 105,073,619–105,073,677, 59 basesExon 8: 105,074,643–105,074,815, 173 basesExon 9: 105,076,043–105,076,081, 39 basesExon 10: 105,076,963–105,077,193, 231 basesExon 11: 105,077,303–105,077,433, 131 basesExon 12: 105,078,846–105,078,963, 118 basesExon 13: 105,081,688–105,081,797, 110 basesExon 14: 105,090,009–105,090,273, 265 basesExon 15: 105,091,216–105,091,314, 99 basesExon 16: 105,101,425–105,101,589, 165 basesExon 17: 105,101,886–105,102,194, 309 basesExon 18: 105,105,439–105,105,693, 255 basesExon 19: 105,105,859–105,106,003, 145 basesExon 20: 105,106,522–105,106,772, 251 basesExon 21: 105,107,166–105,107,222, 57 basesExon 22: 105,107,362–105,107,925, 564 basesExon 23: 105,108,942–105,109,228, 287 basesExon 24: 105,110,280–105,110,368, 89 basesExon 25: 105,110,477–105,110,602, 126 basesExon 26: 105,110,771–105,110,868, 98 basesExon 27: 105,111,825–105,115,019, 3,195 bases1510152025275′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.8 kb of the gene's 100.8 kb; 5,577 of those bases code for the protein.

How a genome test reads KMT2E

70

positions in KMT2E where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 100.8 kb of KMT2E, introns included, not only the 7.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KMT2E gene: lysine methyltransferase 2E (inactive). Retrieved 17 October 2026, from https://dantelabs.com/genes/kmt2e

Vancouver

Dante Labs. KMT2E gene: lysine methyltransferase 2E (inactive) [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kmt2e

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