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Gene

WNK4

WNK lysine deficient protein kinase 4

Summary

Cytogenetic location
17q21.2
Coordinates
Chromosome 17: 42,780,610–42,797,066 (GRCh38)
Exons
19 exons across 16.5 kb
Protein
1,243 amino acids
Inheritance
Autosomal dominant
Previous symbols
PRKWNK4
MANE Select transcript
ENST00000246914.10NM_032387.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Monogenic Hypertension & Mineralocorticoid Disorders

    • Pseudohypoaldosteronism Type 2 (Gordon Syndrome)Autosomal dominant

      A condition caused by changes in WNK1, WNK4, KLHL3 or CUL3 that causes high blood pressure with high potassium and acid build-up in the blood.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing about it points to thiazide diuretics, which usually correct both the blood pressure and the potassium.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How WNK4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where WNK4 sits. WNK4 and 37 genes near it on chromosome 17, from 42,288,838 to 43,288,837.Chromosome 1717q21.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.342.4 Mb42.6 Mb42.8 Mb43 Mb43.2 MbSTAT5A: 42,287,547–42,311,943, forward strandSTAT5ASTAT3: 42,313,322–42,388,574, reverse strandSTAT3CAVIN1: 42,402,449–42,423,322, reverse strandCAVIN1ATP6V0A1: 42,458,823–42,522,582, forward strandATP6V0A1NAGLU: 42,536,216–42,544,449, forward strandHSD17B1: 42,552,920–42,555,217, forward strandCOASY: 42,561,467–42,566,277, forward strandMLX: 42,567,067–42,573,239, forward strandMLXPSMC3IP: 42,572,310–42,577,831, reverse strandPSMC3IPRETREG3: 42,579,508–42,610,623, reverse strandRETREG3TUBG1: 42,609,411–42,615,253, forward strandTUBG1TUBG2: 42,659,223–42,667,007, forward strandTUBG2PLEKHH3: 42,667,914–42,677,064, reverse strandPLEKHH3CCR10: 42,678,889–42,683,917, reverse strandCCR10CNTNAP1: 42,682,368–42,699,993, forward strandCNTNAP1EZH1: 42,700,270–42,745,069, reverse strandEZH1RAMP2: 42,758,447–42,763,537, forward strandVPS25: 42,773,439–42,779,600, forward strandVPS25WNK4: 42,780,610–42,797,066, forward strandWNK4COA3: 42,793,154–42,798,719, reverse strandCOA3CNTD1: 42,798,800–42,811,587, forward strandCNTD1BECN1: 42,809,108–42,833,350, reverse strandPSME3: 42,824,385–42,843,760, forward strandPSME3AOC2: 42,844,574–42,850,707, forward strandAOC2AOC3: 42,851,130–42,858,130, forward strandAOC3G6PC1: 42,900,722–42,923,502, forward strandG6PC1AARSD1: 42,950,424–42,964,498, reverse strandAARSD1PTGES3L-AARSD1: 42,950,526–42,980,528, reverse strandPTGES3L-AARSD1PTGES3L: 42,968,035–42,980,502, reverse strandPTGES3LRUNDC1: 42,980,552–42,995,142, forward strandRUNDC1RPL27: 42,998,265–43,002,973, forward strandVAT1: 42,999,182–43,025,123, reverse strandIFI35: 43,006,740–43,014,638, forward strandRND2: 43,025,210–43,047,509, forward strandBRCA1: 43,044,292–43,170,245, reverse strandBRCA1NBR1: 43,170,317–43,211,690, forward strandNBR1TMEM106A: 43,211,835–43,220,041, forward strandTMEM106ACCDC200: 43,216,941–43,305,397, reverse strandCCDC200Diagram of WNK4: 19 exons on the forward strand of chromosome 17Exon 7: 2 known disease-causing sitesExon 16: 1 known disease-causing siteExon 1: 42,780,610–42,781,316, 707 basesExon 2: 42,782,758–42,782,930, 173 basesExon 3: 42,783,937–42,784,157, 221 basesExon 4: 42,784,422–42,784,579, 158 basesExon 5: 42,785,097–42,785,185, 89 basesExon 6: 42,785,266–42,785,482, 217 basesExon 7: 42,787,278–42,787,542, 265 basesExon 8: 42,787,778–42,787,899, 122 basesExon 9: 42,788,130–42,788,188, 59 basesExon 10: 42,788,290–42,788,407, 118 basesExon 11: 42,788,681–42,788,797, 117 basesExon 12: 42,793,592–42,793,729, 138 basesExon 13: 42,794,614–42,794,668, 55 basesExon 14: 42,794,772–42,795,382, 611 basesExon 15: 42,795,461–42,795,521, 61 basesExon 16: 42,795,625–42,796,033, 409 basesExon 17: 42,796,123–42,796,322, 200 basesExon 18: 42,796,481–42,796,578, 98 basesExon 19: 42,796,686–42,797,066, 381 bases151015195′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.2 kb of the gene's 16.5 kb; 3,732 of those bases code for the protein.

How a genome test reads WNK4

3

positions in WNK4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 16.5 kb of WNK4, introns included, not only the 4.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). WNK4 gene: WNK lysine deficient protein kinase 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/wnk4

Vancouver

Dante Labs. WNK4 gene: WNK lysine deficient protein kinase 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/wnk4

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