Skip to content
Use your HSA or FSA funds

Gene

TMEM98

transmembrane protein 98

Summary

Cytogenetic location
17q11.2
Coordinates
Chromosome 17: 32,928,153–32,944,315 (GRCh38)
Exons
8 exons across 16.2 kb
Protein
226 amino acids
Also known as
DKFZP564K1964
MANE Select transcript
ENST00000579849.6NM_015544.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Microphthalmia, Anophthalmia & Coloboma

    • Isolated Anophthalmia, Microphthalmia & Coloboma

      Eye malformations without other features, including nanophthalmos, caused by changes in genes such as VSX2, RAX, MFRP, PRSS56 and others.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      People with nanophthalmos (often MFRP or PRSS56) have a raised risk of angle-closure glaucoma and need regular eye checks; a genetic diagnosis also informs recurrence risk.

How TMEM98 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 17, with a bracket where TMEM98 sits. TMEM98 and 6 genes near it on chromosome 17, from 32,436,234 to 33,436,233.Chromosome 1717q11.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.332.6 Mb32.8 Mb33 Mb33.2 Mb33.4 MbPSMD11: 32,444,379–32,483,319, forward strandPSMD11CDK5R1: 32,486,156–32,491,253, forward strandCDK5R1MYO1D: 32,492,522–32,877,200, reverse strandMYO1DH2BN1: 32,895,433–32,906,586, forward strandH2BN1TMEM98: 32,928,153–32,944,315, forward strandTMEM98SPACA3: 32,970,376–32,997,877, forward strandSPACA3ASIC2: 33,013,087–34,174,964, reverse strandASIC2Diagram of TMEM98: 8 exons on the forward strand of chromosome 17Exon 1: 32,928,153–32,928,237, 85 basesExon 2: 32,931,327–32,931,402, 76 basesExon 3: 32,931,475–32,931,659, 185 basesExon 4: 32,933,174–32,933,305, 132 basesExon 5: 32,934,291–32,934,324, 34 basesExon 6: 32,936,332–32,936,447, 116 basesExon 7: 32,939,477–32,939,536, 60 basesExon 8: 32,940,786–32,944,315, 3,530 bases124685′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.2 kb of the gene's 16.2 kb; 681 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TMEM98 gene: transmembrane protein 98. Retrieved 16 October 2026, from https://dantelabs.com/genes/tmem98

Vancouver

Dante Labs. TMEM98 gene: transmembrane protein 98 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tmem98

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test