Skip to content
Use your HSA or FSA funds

Gene

LRMDA

leucine rich melanocyte differentiation associated

Summary

Cytogenetic location
10q22.2-q22.3
Coordinates
Chromosome 10: 75,431,624–76,560,168 (GRCh38)
Exons
7 exons across 1,128.5 kb
Protein
226 amino acids
Inheritance
Autosomal recessive
Also known as
CDA017, OCA7
Previous symbols
C10orf11
MANE Select transcript
ENST00000611255.5NM_001305581.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How LRMDA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where LRMDA sits. LRMDA and 11 genes near it on chromosome 10, from 74,303,079 to 77,688,713.Chromosome 1010q22.2-q22.3p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.374.5 Mb75 Mb75.5 Mb76 Mb76.5 Mb77 Mb77.5 MbADK: 74,151,185–74,709,963, forward strandADKKAT6B: 74,824,912–75,032,631, forward strandKAT6BDUSP29: 75,037,472–75,073,655, reverse strandDUSP13A: 75,094,427–75,109,251, reverse strandDUSP13ADUSP13B: 75,094,432–75,109,206, reverse strandDUSP13B: 75,094,432–75,106,499, reverse strandSAMD8: 75,099,586–75,182,128, forward strandSAMD8VDAC2: 75,209,978–75,231,463, forward strandVDAC2COMTD1: 75,230,309–75,236,088, reverse strandCOMTD1ZNF503: 75,397,830–75,402,399, reverse strandZNF503LRMDA: 75,431,624–76,560,168, forward strandLRMDAKCNMA1: 76,869,601–77,638,908, reverse strandKCNMA1Diagram of LRMDA: 7 exons on the forward strand of chromosome 10Exon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 1: 75,431,624–75,431,754, 131 basesExon 2: 75,438,394–75,438,494, 101 basesExon 3: 76,036,008–76,036,134, 127 basesExon 4: 76,047,164–76,047,303, 140 basesExon 5: 76,058,666–76,058,783, 118 basesExon 6: 76,324,401–76,324,485, 85 basesExon 7: 76,557,209–76,560,168, 2,960 bases1575′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.7 kb of the gene's 1,128.5 kb; 681 of those bases code for the protein.

How a genome test reads LRMDA

2

positions in LRMDA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 1,128.5 kb of LRMDA, introns included, not only the 3.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LRMDA gene: leucine rich melanocyte differentiation associated. Retrieved 16 October 2026, from https://dantelabs.com/genes/lrmda

Vancouver

Dante Labs. LRMDA gene: leucine rich melanocyte differentiation associated [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/lrmda

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test