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Gene

TRDN

triadin

Summary

Cytogenetic location
6q22.31
Coordinates
Chromosome 6: 123,216,339–123,636,950 (GRCh38)
Exons
41 exons across 420.6 kb
Protein
729 amino acids
Also known as
TRISK
MANE Select transcript
ENST00000334268.9NM_006073.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Catecholaminergic Polymorphic Ventricular Tachycardia

    • Ventricular Tachycardia, Familial

      An instance of ventricular tachycardia that is caused by an inherited modification of the individual's genome.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      • On the ACMG secondary findings list
    • Polymorphic Ventricular Tachycardia

      A ventricular tachycardia that is irregular in rate and rhythm.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      • On the ACMG secondary findings list

  • Long QT Syndrome

    • A disorder of cardiac repolarisation marked by a prolonged QT interval and a risk of dangerous ventricular arrhythmias such as torsades de pointes.

      • ClinGen rates the link strong
      • 2 GenCC submitters rate it definitive or strong
      • On the ACMG secondary findings list
      What knowing changes

      Beta-blockers, ICD placement, activity restriction, genetic counseling

How TRDN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
  • Variants with a page
Chromosome 6, with a bracket where TRDN sits. TRDN and 3 genes near it on chromosome 6, from 122,795,727 to 124,057,562.Chromosome 66q22.31p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27122.8 Mb123 Mb123.2 Mb123.4 Mb123.6 Mb123.8 Mb124 MbSMPDL3A: 122,788,456–122,811,801, forward strandSMPDL3ACLVS2: 122,996,029–123,072,925, forward strandCLVS2TRDN: 123,216,339–123,636,950, reverse strandTRDNNKAIN2: 123,803,812–124,825,739, forward strandNKAIN2Diagram of TRDN: 41 exons on the reverse strand of chromosome 6Exon 22: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 8: 4 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 6: 7 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 4: 1 known disease-causing siteExon 3: 4 known disease-causing sitesExon 2: 6 known disease-causing sitesExon 1: 1 known disease-causing siteExon 41: 123,216,339–123,218,740, 2,402 basesExon 40: 123,221,487–123,221,522, 36 basesExon 39: 123,224,093–123,224,131, 39 basesExon 38: 123,252,412–123,252,435, 24 basesExon 37: 123,255,081–123,255,125, 45 basesExon 36: 123,255,867–123,255,902, 36 basesExon 35: 123,259,624–123,259,662, 39 basesExon 34: 123,260,612–123,260,638, 27 basesExon 33: 123,265,318–123,265,338, 21 basesExon 32: 123,267,707–123,267,751, 45 basesExon 31: 123,269,849–123,269,866, 18 basesExon 30: 123,271,139–123,271,186, 48 basesExon 29: 123,272,964–123,273,011, 48 basesExon 28: 123,273,337–123,273,363, 27 basesExon 27: 123,274,641–123,274,670, 30 basesExon 26: 123,278,318–123,278,347, 30 basesExon 25: 123,279,056–123,279,082, 27 basesExon 24: 123,316,457–123,316,495, 39 basesExon 23: 123,331,879–123,331,929, 51 basesExon 22: 123,337,619–123,337,669, 51 basesExon 21: 123,352,539–123,352,586, 48 basesExon 20: 123,366,135–123,366,182, 48 basesExon 19: 123,375,605–123,375,631, 27 basesExon 18: 123,377,716–123,377,742, 27 basesExon 17: 123,377,866–123,377,898, 33 basesExon 16: 123,381,370–123,381,390, 21 basesExon 15: 123,382,118–123,382,147, 30 basesExon 14: 123,388,522–123,388,551, 30 basesExon 13: 123,393,624–123,393,677, 54 basesExon 12: 123,438,063–123,438,122, 60 basesExon 11: 123,438,944–123,439,003, 60 basesExon 10: 123,464,906–123,464,983, 78 basesExon 9: 123,497,193–123,497,252, 60 basesExon 8: 123,503,719–123,503,901, 183 bases. 1 variant with a page in exon 8. List themExon 7: 123,512,303–123,512,362, 60 basesExon 6: 123,516,141–123,516,206, 66 bases. 2 variants with a page in exon 6. List themExon 5: 123,530,506–123,530,565, 60 bases. 1 variant with a page in exon 5. List themExon 4: 123,547,340–123,547,372, 33 basesExon 3: 123,548,454–123,548,612, 159 basesExon 2: 123,570,923–123,571,132, 210 bases. 1 variant with a page in exon 2. List themExon 1: 123,636,754–123,636,950, 197 bases412515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.6 kb of the gene's 420.6 kb; 2,190 of those bases code for the protein.

How a genome test reads TRDN

52

positions in TRDN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 420.6 kb of TRDN, introns included, not only the 4.6 kb of exons.

Variants with a page (8)

The TRDN variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.

VariantHGVS c.Exon or intronPosition (GRCh38)ClinVar classificationReview status
c.22+29A>GIntron 1123,636,725Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
c.391+1G>AIntron 3123,548,453Likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
c.550+1_550+2insAIntron 6123,516,139Likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
D18Afs*14c.53_56delExon 2123,571,098Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
E168Xc.502G>TExon 6123,516,189Pathogenic/likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
E178Kfs*45c.531delExon 6123,516,159Pathogenic/likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
Q205Xc.613C>TExon 8123,503,899Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
V162Lfs*13c.483delExon 5123,530,506Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TRDN gene: triadin. Retrieved 16 October 2026, from https://dantelabs.com/genes/trdn

Vancouver

Dante Labs. TRDN gene: triadin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/trdn

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