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Gene

MYLK3

myosin light chain kinase 3

Summary

Cytogenetic location
16q11.2
Coordinates
Chromosome 16: 46,702,282–46,748,344 (GRCh38)
Exons
13 exons across 46.1 kb
Protein
819 amino acids
Also known as
caMLCK, MLCK
MANE Select transcript
ENST00000394809.9NM_182493.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Dilated Cardiomyopathy

    • Enlargement and weakening of the left ventricle not explained by coronary artery or valve disease; inherited forms involve TTN, LMNA, RBM20, FLNC, BAG3, DSP, MYH7, TNNT2, DES, PLN and many other genes, and include Barth syndrome and the Emery-Dreifuss muscular dystrophies.

      • ClinGen rates the link moderate
      What knowing changes

      Knowing a genetic cause supports earlier heart monitoring and family screening, and for genes with a high arrhythmia risk such as LMNA, FLNC and RBM20 it informs decisions about rhythm monitoring and implantable defibrillators.

How MYLK3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 16, with a bracket where MYLK3 sits. MYLK3 and 8 genes near it on chromosome 16, from 46,225,313 to 47,225,312.Chromosome 1616q11.2p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.346.4 Mb46.6 Mb46.8 Mb47 Mb47.2 MbSHCBP1: 46,578,565–46,621,404, reverse strandSHCBP1VPS35: 46,656,132–46,689,518, reverse strandVPS35ORC6: 46,689,301–46,698,399, forward strandORC6MYLK3: 46,702,282–46,748,344, reverse strandMYLK3HDIP1: 46,796,603–46,831,476, reverse strandHDIP1GPT2: 46,882,857–46,931,299, forward strandGPT2DNAJA2: 46,955,362–46,973,709, reverse strandDNAJA2NETO2: 47,077,703–47,144,028, reverse strandNETO2ITFG1: 47,154,387–47,464,149, reverse strandITFG1Diagram of MYLK3: 13 exons on the reverse strand of chromosome 16Exon 13: 46,702,282–46,707,763, 5,482 basesExon 12: 46,709,539–46,709,671, 133 basesExon 11: 46,710,637–46,710,789, 153 basesExon 10: 46,712,648–46,712,776, 129 basesExon 9: 46,721,123–46,721,193, 71 basesExon 8: 46,727,236–46,727,377, 142 basesExon 7: 46,729,024–46,729,133, 110 basesExon 6: 46,729,594–46,729,687, 94 basesExon 5: 46,730,593–46,730,698, 106 basesExon 4: 46,732,208–46,732,668, 461 basesExon 3: 46,737,711–46,738,143, 433 basesExon 2: 46,740,057–46,740,147, 91 basesExon 1: 46,747,717–46,748,344, 628 bases131210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8 kb of the gene's 46.1 kb; 2,460 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MYLK3 gene: myosin light chain kinase 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/mylk3

Vancouver

Dante Labs. MYLK3 gene: myosin light chain kinase 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/mylk3

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