Trait
Depleted blood volume
Clinical name: Hypovolemia
An decrease in the amount of intravascular fluid, particularly in the volume of the circulating blood.
Summary
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Depleted blood volume, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test33 genes linked to Depleted blood volume
Changes in these genes cause rare conditions in which Depleted blood volume is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCC8ATP binding cassette subfamily C member 8 | Very often (80–99%) | In 1 condition |
| CYP11A1cytochrome P450 family 11 subfamily A member 1 | Very often (80–99%) | In 2 conditions |
| GCKglucokinase | Very often (80–99%) | In 1 condition |
| INSinsulin | Very often (80–99%) | In 1 condition |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Very often (80–99%) | In 1 condition |
| PDX1pancreatic and duodenal homeobox 1 | Very often (80–99%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Very often (80–99%) | In 1 condition |
| MYO5Bmyosin VB | Often (30–79%) | In 1 condition |
| STX3syntaxin 3 | Often (30–79%) | In 1 condition |
| ACTA2actin alpha 2, smooth muscle | Sometimes (5–29%) | In 1 condition |
| AQP2aquaporin 2 | Sometimes (5–29%) | In 1 condition |
| AVPR2arginine vasopressin receptor 2 | Sometimes (5–29%) | In 1 condition |
| EFEMP2EGF-like fibulin extracellular matrix protein 2 | Sometimes (5–29%) | In 1 condition |
| ELNelastin | Sometimes (5–29%) | In 1 condition |
| FBN1fibrillin 1 | Sometimes (5–29%) | In 1 condition |
| FOXE3forkhead box E3 | Sometimes (5–29%) | In 1 condition |
| FSHRfollicle stimulating hormone receptor | Sometimes (5–29%) | In 1 condition |
| HEY2hes related family bHLH transcription factor with YRPW motif 2 | Sometimes (5–29%) | In 1 condition |
| LOXlysyl oxidase | Sometimes (5–29%) | In 1 condition |
| MAT2Amethionine adenosyltransferase 2A | Sometimes (5–29%) | In 1 condition |
| MFAP5microfibril associated protein 5 | Sometimes (5–29%) | In 1 condition |
| MYH11myosin heavy chain 11 | Sometimes (5–29%) | In 1 condition |
| MYLKmyosin light chain kinase | Sometimes (5–29%) | In 1 condition |
| PRKG1protein kinase cGMP-dependent 1 | Sometimes (5–29%) | In 1 condition |
| SMAD2SMAD family member 2 | Sometimes (5–29%) | In 1 condition |
| SMAD3SMAD family member 3 | Sometimes (5–29%) | In 1 condition |
| SMAD4SMAD family member 4 | Sometimes (5–29%) | In 1 condition |
| TGFB2transforming growth factor beta 2 | Sometimes (5–29%) | In 1 condition |
| TGFB3transforming growth factor beta 3 | Sometimes (5–29%) | In 1 condition |
| TGFBR1transforming growth factor beta receptor 1 | Sometimes (5–29%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Sometimes (5–29%) | In 1 condition |
| THSD4thrombospondin type 1 domain containing 4 | Sometimes (5–29%) | In 1 condition |
| CTNScystinosin, lysosomal cystine transporter | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks