Trait
Dural ectasia
A widening or ballooning of the dural sac surrounding the spinal cord usually at the lumbosacral level.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test25 genes linked to Dural ectasia
Changes in these genes cause rare conditions in which Dural ectasia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| EFEMP1EGF-like fibulin extracellular matrix protein 1 | Always | In 1 condition |
| FBN1fibrillin 1 | Always | In 4 conditions |
| TGFBR1transforming growth factor beta receptor 1 | Always | In 2 conditions |
| NOTCH3notch receptor 3 | Very often (80–99%) | In 2 conditions |
| MFAP5microfibril associated protein 5 | Often (30–79%) | In 2 conditions |
| SMAD3SMAD family member 3 | Often (30–79%) | In 3 conditions |
| TGFB2transforming growth factor beta 2 | Often (30–79%) | In 2 conditions |
| TGFBR2transforming growth factor beta receptor 2 | Often (30–79%) | In 2 conditions |
| ACTA2actin alpha 2, smooth muscle | Sometimes (5–29%) | In 1 condition |
| EFEMP2EGF-like fibulin extracellular matrix protein 2 | Sometimes (5–29%) | In 1 condition |
| ELNelastin | Sometimes (5–29%) | In 1 condition |
| FOXE3forkhead box E3 | Sometimes (5–29%) | In 1 condition |
| HEY2hes related family bHLH transcription factor with YRPW motif 2 | Sometimes (5–29%) | In 1 condition |
| LOXlysyl oxidase | Sometimes (5–29%) | In 2 conditions |
| MAT2Amethionine adenosyltransferase 2A | Sometimes (5–29%) | In 1 condition |
| MYH11myosin heavy chain 11 | Sometimes (5–29%) | In 1 condition |
| MYLKmyosin light chain kinase | Sometimes (5–29%) | In 1 condition |
| PRKG1protein kinase cGMP-dependent 1 | Sometimes (5–29%) | In 1 condition |
| RASA1RAS p21 protein activator 1 | Sometimes (5–29%) | In 1 condition |
| RNU5B-1RNA, U5B small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| SMAD2SMAD family member 2 | Sometimes (5–29%) | In 1 condition |
| SMAD4SMAD family member 4 | Sometimes (5–29%) | In 1 condition |
| TGFB3transforming growth factor beta 3 | Sometimes (5–29%) | In 1 condition |
| THSD4thrombospondin type 1 domain containing 4 | Sometimes (5–29%) | In 1 condition |
| NF1neurofibromin 1 | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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