Traits

Traits linked to STRADA

STE20 related adaptor alpha

The Human Phenotype Ontology links 49 traits to STRADA, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Big midface	Always
Full lower lip	Always
Full upper lip	Always
Large forehead	Always
Long face	Always
Wide mouth	Always
Wide nasal bridge	Always
Abnormal facial shape	Very often (80–99%)
Big calvaria	Very often (80–99%)
Decreased facial muscle tone	Sometimes (5–29%)
Drooling	Sometimes (5–29%)
High forehead	Sometimes (5–29%)
Highly arched eyebrow	Sometimes (5–29%)
Narrow face	Sometimes (5–29%)
Open mouth	Sometimes (5–29%)
Tented mouth	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Enlarged brain	Very often (80–99%)
Epilepsy	Very often (80–99%)
Global developmental delay	Very often (80–99%)
Infantile spasms	Very often (80–99%)
Cerebral white matter hypoplasia	Often (30–79%)
Periventricular white matter hyperintensities	Often (30–79%)
Ventriculomegaly	Often (30–79%)
Absent speech development	Sometimes (5–29%)
Focal impaired awareness seizure	Sometimes (5–29%)
Interictal epileptiform activity	Sometimes (5–29%)
Repeated seizures without recovery between them	Sometimes (5–29%)
Severe global developmental delay	Sometimes (5–29%)
Abnormal gait	Not recorded
Astrocytosis	Not recorded
Inability to walk	Not recorded
Intellectual disability	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Always
Decreased muscle mass	Sometimes (5–29%)
Double-Jointed	Sometimes (5–29%)
Severely decreased muscle tone	Sometimes (5–29%)
Generalized decreased muscle tone	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal cardiovascular system morphology	Sometimes (5–29%)
An opening in the wall separating the top two chambers of the heart	Sometimes (5–29%)
Cardiac failure	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
High levels of amniotic fluid	Always
Premature birth	Very often (80–99%)

Abnormality of the eye

Trait	How often it is seen
Wide-set eyes	Always
Cross-eyed	Not recorded

Growth abnormality

Trait	How often it is seen
Faltering weight	Sometimes (5–29%)
Slender build	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties	Sometimes (5–29%)

Abnormality of the endocrine system

Trait	How often it is seen
Diabetes insipidus	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Increased calcium level in kidney	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to STRADA and how often each is seen. Find out more at hpo.jax.org.

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