Traits

Traits linked to PRR12

proline rich 12

The Human Phenotype Ontology links 73 traits to PRR12, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Often (30–79%)
Blocked tear duct	Often (30–79%)
Broad opening between the eyelids	Often (30–79%)
Deep bite	Often (30–79%)
Distichiasis	Often (30–79%)
Downturned corners of mouth	Often (30–79%)
Downward slanting of the opening between the eyelids	Often (30–79%)
Eyelids stay open	Often (30–79%)
Highly arched eyebrow	Often (30–79%)
Hooded upper eyelid	Often (30–79%)
Long eyelashes	Often (30–79%)
Midface retrusion	Often (30–79%)
Monobrow	Often (30–79%)
Prominent brow	Often (30–79%)
Receding chin	Often (30–79%)
Short uvula	Often (30–79%)
Submucous cleft hard palate	Often (30–79%)
Thick eyebrow	Often (30–79%)
Tongue tied	Often (30–79%)
Torus palatinus	Often (30–79%)
Widely spaced teeth	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Outward facing eye ball	Always
Stellate iris	Always
Abnormally small eyeball	Often (30–79%)
Blue eyes	Often (30–79%)
Cat eye	Often (30–79%)
Close sighted	Often (30–79%)
Deeply set eye	Often (30–79%)
Drooping upper eyelid	Often (30–79%)
Involuntary, rapid, rhythmic eye movements	Often (30–79%)
Lazy eye	Often (30–79%)
Lens coloboma	Often (30–79%)
Peters anomaly	Often (30–79%)
Speckled iris	Often (30–79%)
Clouding of the lens of the eye	Sometimes (5–29%)
Cornea of eye less than 10mm in diameter	Sometimes (5–29%)
Farsightedness	Sometimes (5–29%)
Glaucoma	Sometimes (5–29%)
Hypoplasia of the fovea	Sometimes (5–29%)
Remnants of the hyaloid vascular system	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Always
Intellectual disability	Always
Motor delay	Always
Anxiety	Often (30–79%)
Attention deficit	Often (30–79%)
Autism spectrum disorder	Often (30–79%)
Brisk reflexes	Often (30–79%)
Difficulty falling asleep	Often (30–79%)
Excessive daytime sleepiness	Often (30–79%)
Global developmental delay	Often (30–79%)
Obstructive sleep apnea	Often (30–79%)
Periventricular leukomalacia	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Back knee	Often (30–79%)
Curvature of little finger	Often (30–79%)
Deep palm line	Often (30–79%)
Dropped arches	Often (30–79%)
Finger joint hyperextensibility	Often (30–79%)
Prominent fingertip pads	Often (30–79%)
Tapered finger	Often (30–79%)
Tibial torsion	Often (30–79%)
Winged shoulder blade	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Cupped ear	Often (30–79%)
Deafness in one ear	Often (30–79%)
Earlobe crease	Often (30–79%)
Low-set ears	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Small nail	Often (30–79%)
Spinal dimple	Often (30–79%)
Brittle hair	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Funnel chest	Often (30–79%)
Low muscle tone in trunk	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Patent foramen ovale	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Umbilical hernia	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Short stature	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PRR12 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test