Skip to content
Use your HSA or FSA funds

Trait

Poorly functioning veins

Clinical name: Venous insufficiency

HPO HP:0005293

Summary

Body system
Abnormality of the cardiovascular system

11 genes linked to Poorly functioning veins

Changes in these genes cause rare conditions in which Poorly functioning veins is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
THBS2thrombospondin 2AlwaysIn 1 condition
AGGF1angiogenic factor with G-patch and FHA domains 1Very often (80–99%)In 1 condition
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaVery often (80–99%)In 1 condition
PTENphosphatase and tensin homologVery often (80–99%)In 2 conditions
ATP7AATPase copper transporting alphaOften (30–79%)In 2 conditions
NDPnorrin cystine knot growth factor NDPOften (30–79%)In 1 condition
GJC2gap junction protein gamma 2Sometimes (5–29%)In 1 condition
GNAQG protein subunit alpha qSometimes (5–29%)In 1 condition
PROCprotein C, inactivator of coagulation factors Va and VIIIaSometimes (5–29%)In 1 condition
PROS1protein SSometimes (5–29%)In 1 condition
SMOC1SPARC related modular calcium binding 1Sometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal vein

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test