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Gene

LIMS2

LIM zinc finger domain containing 2

Summary

Cytogenetic location
2q14.3
Coordinates
Chromosome 2: 127,638,426–127,675,530 (GRCh38)
Exons
10 exons across 37.1 kb
Protein
341 amino acids
Also known as
PINCH2, PINCH-2
MANE Select transcript
ENST00000355119.9NM_001161403.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads LIMS2 yet. The test sequences your whole genome, so your data includes it all the same.

How LIMS2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where LIMS2 sits. LIMS2 and 13 genes near it on chromosome 2, from 127,156,978 to 128,156,977.Chromosome 22q14.3p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3127.2 Mb127.4 Mb127.6 Mb127.8 Mb128 MbCYP27C1: 127,183,832–127,220,385, reverse strandCYP27C1ERCC3: 127,257,285–127,294,188, reverse strandERCC3MAP3K2: 127,298,668–127,388,465, reverse strandMAP3K2PROC: 127,415,933–127,429,762, forward strandPROCIWS1: 127,436,207–127,526,886, reverse strandIWS1MYO7B: 127,535,683–127,637,729, forward strandMYO7BLIMS2: 127,638,426–127,675,530, reverse strandLIMS2GPR17: 127,645,864–127,656,181, forward strandGPR17WDR33: 127,701,027–127,811,195, reverse strandWDR33SFT2D3: 127,701,497–127,705,242, forward strandSFT2D3POLR2D: 127,843,553–127,858,163, reverse strandPOLR2DAMMECR1L: 127,861,630–127,885,967, reverse strandAMMECR1LSAP130: 127,941,217–128,028,124, reverse strandSAP130UGGT1: 128,091,151–128,195,677, forward strandUGGT1Diagram of LIMS2: 10 exons on the reverse strand of chromosome 2Exon 5: 1 known disease-causing siteExon 10: 127,638,426–127,639,428, 1,003 basesExon 9: 127,640,070–127,640,145, 76 basesExon 8: 127,640,270–127,640,318, 49 basesExon 7: 127,640,896–127,640,988, 93 basesExon 6: 127,642,049–127,642,199, 151 basesExon 5: 127,642,923–127,643,072, 150 basesExon 4: 127,654,424–127,654,544, 121 basesExon 3: 127,654,830–127,654,896, 67 basesExon 2: 127,657,403–127,657,562, 160 basesExon 1: 127,675,014–127,675,530, 517 bases10864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 37.1 kb; 1,026 of those bases code for the protein.

Sequencing LIMS2

2

positions in LIMS2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 37.1 kb of LIMS2, introns included, not only the 2.4 kb of exons.

Traits linked to LIMS2

The Human Phenotype Ontology lists these as features of the rare conditions LIMS2 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LIMS2 gene: LIM zinc finger domain containing 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/lims2

Vancouver

Dante Labs. LIMS2 gene: LIM zinc finger domain containing 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lims2

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