Traits

Traits linked to PRMT7

protein arginine methyltransferase 7

The Human Phenotype Ontology links 87 traits to PRMT7, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Broad head shape	Always
Decreased volume of lip	Always
Flattened bony protrusion above eyes	Always
Hairy forehead	Always
Long philtrum	Always
Redundant neck skin	Always
Short neck	Always
Abnormal facial shape	Very often (80–99%)
Flat face	Often (30–79%)
Flat nose	Often (30–79%)
Gum enlargement	Often (30–79%)
Nasal tip, upturned	Often (30–79%)
Prominent forehead	Often (30–79%)
Short nose	Often (30–79%)
Short opening between the eyelids	Often (30–79%)
Zygomatic flattening	Often (30–79%)
Abnormally small head	Sometimes (5–29%)
Broad nasal tip	Sometimes (5–29%)
Collapsed nostrils	Sometimes (5–29%)
Dacryocystitis	Sometimes (5–29%)
Dental crowding	Sometimes (5–29%)
Depressed nasal bridge	Sometimes (5–29%)
Eye folds	Sometimes (5–29%)
Receding chin	Sometimes (5–29%)
Skin tag in front of the ear	Sometimes (5–29%)
Wide nasal bridge	Sometimes (5–29%)
Frontal bossing	Not recorded
High palate	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Delayed ability to walk	Always
Delayed CNS myelination	Always
Delayed speech and language development	Always
Global developmental delay	Always
Severe global developmental delay	Always
Short attention span	Always
Sudden loss of muscle tone	Always
Tethered cord	Always
Intellectual disability	Very often (80–99%)
Abnormal shape of brain	Often (30–79%)
Epilepsy	Often (30–79%)
Intellectual disability, mild	Often (30–79%)
Intellectual disability, severe	Often (30–79%)
Specific learning disability	Often (30–79%)
Typical absence seizure	Often (30–79%)
Abnormal conus terminalis morphology	Sometimes (5–29%)
IQ between 34 and 49	Sometimes (5–29%)
Pauses in breathing while sleeping	Sometimes (5–29%)
Seizure affecting one half of brain	Sometimes (5–29%)
Thick corpus callosum	Sometimes (5–29%)
Underdevelopment of part of brain called corpus callosum	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Deeply set eye	Always
Drooping upper eyelid	Always
Astigmatism	Often (30–79%)
Cross-eyed	Often (30–79%)
Wide-set eyes	Often (30–79%)
Blue outer white part of eyeball	Sometimes (5–29%)
Notched pupil	Sometimes (5–29%)
Optic disc coloboma	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Short long bone of foot	Always
Short outermost finger bone	Always
Short 4th long bone of foot	Very often (80–99%)
Short fingers or toes	Very often (80–99%)
Shortened long bone of hand	Often (30–79%)
Outward turned elbows	Sometimes (5–29%)
Small kneecap	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Frequent urinary tract infections	Always
Small kidneys	Always
Undescended testes	Often (30–79%)
Vesicoureteral reflux	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Always
Prenatal growth deficiency	Always
Short stature	Always
Obesity	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Acid reflux	Always
Feeding difficulties	Always
Rectum protrudes through anus	Always

Abnormality of the integument

Trait	How often it is seen
Sparse hair	Always
Spinal dimple	Always
Soft skin	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Abnormality of the skeletal system	Very often (80–99%)
Decreased muscle tone in infant	Very often (80–99%)
Low muscle tone	Very often (80–99%)

Abnormality of the endocrine system

Trait	How often it is seen
Pseudohypoparathyroidism	Often (30–79%)
Abnormality of the endocrine system	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
High levels of amniotic fluid	Always

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Eczema	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Softening of voice box tissue	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PRMT7 and how often each is seen. Find out more at hpo.jax.org.

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