Traits

Traits linked to PRKCD

protein kinase C delta

The Human Phenotype Ontology links 41 traits to PRKCD, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the immune system

Trait	How often it is seen
Absent circulating isohemagglutinin	Always
Anticardiolipin IgG antibody positivity	Always
Antinuclear antibody positivity	Always
Recurrent chest infections	Always
Recurrent infections	Always
Decreased circulating complement C3 concentration	Often (30–79%)
Decreased circulating complement C4 concentration	Often (30–79%)
Autoimmunity	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased class-switched memory B cell proportion	Always
Decreased memory B cell proportion	Always
Increased CD21low B cell proportion	Always
Increased total B cell count	Always
Autoimmune hemolytic anemia	Often (30–79%)
Autoimmune thrombocytopenia	Often (30–79%)
Lymphoproliferative disorder	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Enlarged liver and spleen	Always
Follicular hyperplasia	Always
Generalized swelling of lymph nodes	Always
Obstruction of the superior vena cava	Always
Swollen lymph nodes	Always
Swollen lymph nodes in center of chest	Always
Increased spleen size	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Elevated circulating alanine aminotransferase concentration	Always
Elevated circulating aspartate aminotransferase concentration	Always
Elevated circulating C-reactive protein concentration	Always
Episodic fever	Always
High ESR	Always
Persistent EBV viremia	Always

Abnormality of the genitourinary system

Trait	How often it is seen
Frequent urinary tract infections	Always
Membranous nephropathy	Always
Nephrotic syndrome	Always
Stage 5 chronic kidney disease	Often (30–79%)

Abnormal cellular phenotype

Trait	How often it is seen
Abnormal natural killer cell physiology	Always
Increased antibody level in blood	Always

Abnormality of head or neck

Trait	How often it is seen
Recurrent colds	Always
Recurrent sinus disease	Always

Abnormality of the integument

Trait	How often it is seen
Erythematous macule	Always
Hair loss	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Recurrent middle ear infection	Always

Abnormality of the musculoskeletal system

Trait	How often it is seen
Arthritis	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PRKCD and how often each is seen. Find out more at hpo.jax.org.

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