Traits

Traits linked to NOG

noggin

The Human Phenotype Ontology links 102 traits to NOG, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of limbs

Trait	How often it is seen
Fused innermost hinge joints	Always
Fused outermost bones of hand	Always
Fused wrist bones	Always
Abnormality of the ankle	Very often (80–99%)
Broad big toe	Very often (80–99%)
Broad thumb	Very often (80–99%)
Fused ankle bones	Very often (80–99%)
Fused finger bones	Very often (80–99%)
Fusion of wrist bones	Very often (80–99%)
Permanent flexion of the finger	Very often (80–99%)
Short fingers or toes	Very often (80–99%)
Short foot	Very often (80–99%)
Short outermost bone of toe	Very often (80–99%)
Short outermost finger bone	Very often (80–99%)
Short palm	Very often (80–99%)
Short toe	Very often (80–99%)
Type B brachydactyly	Very often (80–99%)
Abnormal shape of long bones of hand	Often (30–79%)
Absent phalangeal crease	Often (30–79%)
Absent proximal finger flexion creases	Often (30–79%)
Absent/small middle bones of toe	Often (30–79%)
Absent/small middle finger bone of the hand	Often (30–79%)
Absent/small outermost bones of toe	Often (30–79%)
Absent/small outermost finger bone of the hand	Often (30–79%)
Attachment of thumb close to wrist	Often (30–79%)
Bilateral single transverse palmar creases	Often (30–79%)
Curvature of finger	Often (30–79%)
Elbow ankylosis	Often (30–79%)
Elbow dislocation	Often (30–79%)
Finger syndactyly	Often (30–79%)
Fused innermost and middle bone of fourth finger	Often (30–79%)
Fused innermost and middle bones of little finger	Often (30–79%)
Fused long bone of hand with innermost finger bone	Often (30–79%)
Fused toes	Often (30–79%)
Radial deviation of finger	Often (30–79%)
Short middle bone of the little finger	Often (30–79%)
Shortened 1st long bone of hand	Often (30–79%)
Webbed fingers	Often (30–79%)
Webbed skin of toes	Often (30–79%)
Abnormality of the wrist	Sometimes (5–29%)
Curvature of 4th toe	Sometimes (5–29%)
Curvature of little finger	Sometimes (5–29%)
Fused innermost and middle bones of 4th toe	Sometimes (5–29%)
Fused innermost and middle pinkie toe bones	Sometimes (5–29%)
Fusion of upper and lower arm bones	Sometimes (5–29%)
Hypoplastic/small middle phalanx of the 5th toe	Sometimes (5–29%)
Outward turned elbows	Sometimes (5–29%)
Short middle bone of 4th finger	Sometimes (5–29%)
Underdeveloped inner large forearm bone	Sometimes (5–29%)
Absent outermost hand bone	Not recorded
Curvature of digit	Not recorded
Dislocated radial head	Not recorded
Lower limb undergrowth	Not recorded
Progressive fusion 2nd-5th proximal interphalangeal joints	Not recorded
Short big toe	Not recorded
Short finger	Not recorded
Short humerus	Not recorded
Short lower limbs	Not recorded
Shortened 5th long bone of hand	Not recorded
Single transverse palmar crease	Not recorded
Webbed 2nd and 3rd toes	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Thin red part of the upper lip	Very often (80–99%)
Limited neck range of motion	Often (30–79%)
Long nose	Often (30–79%)
Low hanging columella	Often (30–79%)
Underdeveloped tissue around nostril	Often (30–79%)
Wide nasal bridge	Often (30–79%)
Asymmetry of the mouth	Sometimes (5–29%)
Facial asymmetry	Sometimes (5–29%)
Upward slanting of the opening between the eyelids	Sometimes (5–29%)
Decreased size of nasal septum	Not recorded
Full upper lip	Not recorded
Narrow face	Not recorded
Short philtrum	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Joint stiffness	Very often (80–99%)
Proximal symphalangism	Very often (80–99%)
Cone-shaped end part of bone	Often (30–79%)
Fused neck	Often (30–79%)
Enlargement of the costochondral junction	Not recorded
Funnel chest	Not recorded
Narrow spinal canal	Not recorded
Short sternum	Not recorded
Underdeveloped spinal processes	Not recorded

Abnormality of the ear

Trait	How often it is seen
Conductive deafness	Very often (80–99%)
Congenital stapes ankylosis	Very often (80–99%)
Stapes ankylosis	Very often (80–99%)
Sensorineural hearing impairment	Often (30–79%)
Bilateral conductive hearing impairment	Sometimes (5–29%)
Hearing abnormality	Sometimes (5–29%)
Progressive conductive hearing impairment	Not recorded

Abnormality of the eye

Trait	How often it is seen
Farsightedness	Very often (80–99%)
Drooping upper eyelid	Often (30–79%)
Astigmatism	Sometimes (5–29%)
Cross-eyed	Sometimes (5–29%)
Lazy eye	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Absent fingernail	Very often (80–99%)
Absent/small nails	Often (30–79%)
Abnormality of the nail	Sometimes (5–29%)
Absent nails	Not recorded
Absent/small toenails	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Waddling gait	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Short stature	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NOG and how often each is seen. Find out more at hpo.jax.org.

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