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Gene

NUDT15

nudix hydrolase 15

Summary

Cytogenetic location
13q14.2
Coordinates
Chromosome 13: 48,037,726–48,047,221 (GRCh38)
Exons
3 exons across 9.5 kb
Protein
164 amino acids
Also known as
MTH2, FLJ10956
MANE Select transcript
ENST00000258662.3NM_018283.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

NUDT15 and medicines

  • Thiopurine tolerance

    Pharmacogenomics

    NUDT15 inactivates thiopurine metabolites. Reduced activity allows them to build up in bone marrow, raising the risk of severe myelosuppression.

    • Relevant if you are treated with azathioprine, mercaptopurine or thioguanine for IBD, leukaemia, or autoimmune disease.
    • Read alongside TPMT — both shape thiopurine dosing, and either alone can require a lower dose.

    Alleles the report reads

    • *1Normal function
    • *3No function

    Results CPIC describes

    • Normal Metabolizer
    • Intermediate Metabolizer
    • Possible Intermediate Metabolizer
    • Poor Metabolizer
    • Indeterminate
    MedicineCPIC levelGuideline
    azathioprineATPMT, NUDT15 and Thiopurines
    mercaptopurineATPMT, NUDT15 and Thiopurines
    thioguanineATPMT, NUDT15 and Thiopurines

    NUDT15*3 is the most common reduced-function allele (notably in East Asian and Hispanic populations); rarer alleles are not assessed.

How NUDT15 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 13, with a bracket where NUDT15 sits. NUDT15 and 6 genes near it on chromosome 13, from 47,542,474 to 48,542,473.Chromosome 1313q14.2p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q3447.6 Mb47.8 Mb48 Mb48.2 Mb48.4 MbSUCLA2: 47,745,736–48,037,968, reverse strandSUCLA2MED4: 48,001,823–48,095,150, reverse strandMED4NUDT15: 48,037,726–48,047,221, forward strandNUDT15ITM2B: 48,232,612–48,270,357, forward strandITM2BRB1: 48,303,710–48,599,436, forward strandRB1LPAR6: 48,327,364–48,444,704, reverse strandLPAR6RCBTB2: 48,488,858–48,536,006, reverse strandRCBTB2Diagram of NUDT15: 3 exons on the forward strand of chromosome 13Exon 1: 48,037,726–48,037,904, 179 basesExon 2: 48,040,920–48,041,116, 197 basesExon 3: 48,045,660–48,047,221, 1,562 bases1235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 9.5 kb; 495 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • CPIC and PharmGKB: the alleles, results and medicines.

Cite this page

APA

Dante Labs. (n.d.). NUDT15 gene: nudix hydrolase 15. Retrieved 17 October 2026, from https://dantelabs.com/genes/nudt15

Vancouver

Dante Labs. NUDT15 gene: nudix hydrolase 15 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nudt15

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