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Gene

TOP2A

DNA topoisomerase II alpha

Summary

Cytogenetic location
17q21.2
Coordinates
Chromosome 17: 40,388,525–40,417,896 (GRCh38)
Exons
35 exons across 29.4 kb
Protein
1,531 amino acids
Also known as
TOP2alpha, TOPIIA
Previous symbols
TOP2
MANE Select transcript
ENST00000423485.6NM_001067.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads TOP2A yet. The test sequences your whole genome, so your data includes it all the same.

How TOP2A is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 17, with a bracket where TOP2A sits. TOP2A and 30 genes near it on chromosome 17, from 39,903,211 to 40,903,210.Chromosome 1717q21.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.340 Mb40.2 Mb40.4 Mb40.6 Mb40.8 MbGSDMB: 39,904,595–39,919,854, reverse strandGSDMBORMDL3: 39,919,927–39,982,186, reverse strandORMDL3LRRC3C: 39,927,725–39,946,538, forward strandLRRC3CGSDMA: 39,953,263–39,977,875, forward strandGSDMAPSMD3: 39,980,800–39,997,960, forward strandPSMD3CSF3: 40,015,361–40,017,816, forward strandCSF3MED24: 40,019,097–40,061,215, reverse strandMED24THRA: 40,058,290–40,093,867, forward strandTHRANR1D1: 40,092,793–40,100,630, reverse strandNR1D1MSL1: 40,121,637–40,136,935, forward strandMSL1CASC3: 40,140,278–40,177,001, forward strandCASC3RAPGEFL1: 40,177,010–40,195,656, forward strandRAPGEFL1WIPF2: 40,218,743–40,284,136, forward strandWIPF2CDC6: 40,287,831–40,304,657, forward strandCDC6RARA: 40,309,165–40,357,643, forward strandRARAGJD3: 40,360,652–40,364,737, reverse strandGJD3TOP2A: 40,388,525–40,417,896, reverse strandTOP2AIGFBP4: 40,442,913–40,460,822, forward strandIGFBP4TNS4: 40,475,828–40,501,630, reverse strandTNS4CCR7: 40,551,081–40,565,478, reverse strandCCR7SMARCE1: 40,624,962–40,648,667, reverse strandSMARCE1: 40,627,356–40,665,141, reverse strandKRT222: 40,654,665–40,665,181, reverse strandKRT222KRT24: 40,697,991–40,703,758, reverse strandKRT24KRT25: 40,748,021–40,755,331, reverse strandKRT25KRT26: 40,766,238–40,772,201, reverse strandKRT26KRT27: 40,776,808–40,782,550, reverse strandKRT27KRT28: 40,792,196–40,799,959, reverse strandKRT28KRT10: 40,817,784–40,822,614, reverse strandKRT10KRT12: 40,860,943–40,867,223, reverse strandKRT12KRT20: 40,872,785–40,885,249, reverse strandKRT20Diagram of TOP2A: 35 exons on the reverse strand of chromosome 17Exon 35: 40,388,525–40,389,647, 1,123 basesExon 34: 40,389,965–40,390,164, 200 basesExon 33: 40,391,506–40,391,640, 135 basesExon 32: 40,392,068–40,392,111, 44 basesExon 31: 40,392,218–40,392,341, 124 basesExon 30: 40,392,585–40,392,737, 153 basesExon 29: 40,395,449–40,395,539, 91 basesExon 28: 40,396,283–40,396,465, 183 basesExon 27: 40,398,558–40,398,641, 84 basesExon 26: 40,398,773–40,398,937, 165 basesExon 25: 40,399,040–40,399,131, 92 basesExon 24: 40,399,872–40,400,067, 196 basesExon 23: 40,400,209–40,400,409, 201 basesExon 22: 40,400,529–40,400,663, 135 basesExon 21: 40,400,850–40,401,081, 232 basesExon 20: 40,402,906–40,403,054, 149 basesExon 19: 40,404,152–40,404,273, 122 basesExon 18: 40,404,377–40,404,491, 115 basesExon 17: 40,404,791–40,404,883, 93 basesExon 16: 40,406,384–40,406,493, 110 basesExon 15: 40,406,584–40,406,689, 106 basesExon 14: 40,406,832–40,406,942, 111 basesExon 13: 40,407,549–40,407,674, 126 basesExon 12: 40,407,967–40,408,124, 158 basesExon 11: 40,408,492–40,408,630, 139 basesExon 10: 40,411,109–40,411,246, 138 basesExon 9: 40,411,354–40,411,455, 102 basesExon 8: 40,411,645–40,411,818, 174 basesExon 7: 40,412,759–40,412,971, 213 basesExon 6: 40,413,195–40,413,292, 98 basesExon 5: 40,413,480–40,413,625, 146 basesExon 4: 40,416,005–40,416,068, 64 basesExon 3: 40,416,422–40,416,512, 91 basesExon 2: 40,416,740–40,416,895, 156 basesExon 1: 40,417,771–40,417,896, 126 bases353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.7 kb of the gene's 29.4 kb; 4,596 of those bases code for the protein.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). TOP2A gene: DNA topoisomerase II alpha. Retrieved 17 October 2026, from https://dantelabs.com/genes/top2a

Vancouver

Dante Labs. TOP2A gene: DNA topoisomerase II alpha [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/top2a

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