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Trait

Cobblestone-like hyperkeratosis

The presence of verrucous, cobblestone-like papules and nodules in a region of skin that is said to have an appearance like that of cobblestones.

HPO HP:0031288

Summary

Body system
Abnormality of the integument

5 genes linked to Cobblestone-like hyperkeratosis

Changes in these genes cause rare conditions in which Cobblestone-like hyperkeratosis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
GJB2gap junction protein beta 2AlwaysIn 1 condition
ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2Often (30–79%)In 1 condition
EPHB4EPH receptor B4Often (30–79%)In 1 condition
KRT10keratin 10Often (30–79%)In 2 conditions
GJB6gap junction protein beta 6Sometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Hyperkeratosis

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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