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Trait

Psychomotor deterioration

Loss of previously present mental and motor abilities.

HPO HP:0002361

Summary

Also called
Psychomotor degeneration
Body system
Abnormality of the nervous system

20 genes linked to Psychomotor deterioration

Changes in these genes cause rare conditions in which Psychomotor deterioration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
CLN3CLN3 lysosomal/endosomal transmembrane protein, batteninAlwaysIn 1 condition
PLP1proteolipid protein 1AlwaysIn 1 condition
ATP6V0A2ATPase H+ transporting V0 subunit a2Very often (80–99%)In 1 condition
ATP6V1AATPase H+ transporting V1 subunit AVery often (80–99%)In 1 condition
ATP6V1E1ATPase H+ transporting V1 subunit E1Very often (80–99%)In 1 condition
PLA2G6phospholipase A2 group VIVery often (80–99%)In 1 condition
PPT1palmitoyl-protein thioesterase 1Very often (80–99%)In 1 condition
COG2component of oligomeric golgi complex 2Often (30–79%)In 1 condition
GALCgalactosylceramidaseOften (30–79%)In 1 condition
PSAPprosaposinOften (30–79%)In 1 condition
KMT2Alysine methyltransferase 2ASometimes (5–29%)In 1 condition
RNASEH1ribonuclease H1Sometimes (5–29%)In 1 condition
RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2BSometimes (5–29%)In 1 condition
GALK1galactokinase 1Rarely (1–4%)In 1 condition
HEXAhexosaminidase subunit alphaNot recordedIn 1 condition
KCNQ2potassium voltage-gated channel subfamily Q member 2Not recordedIn 1 condition
KCNQ3potassium voltage-gated channel subfamily Q member 3Not recordedIn 1 condition
PRRT2proline rich transmembrane protein 2Not recordedIn 1 condition
SCN2Asodium voltage-gated channel alpha subunit 2Not recordedIn 1 condition
SCN8Asodium voltage-gated channel alpha subunit 8Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Mental deterioration

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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