Trait

Torsade de pointes

A type of ventricular tachycardia characterized by polymorphioc QRS complexes that change in amplitue and cycle length, and thus have the appearance of oscillating around the baseline in the EKG.

HPO HP:0001664

Also called: Torsades de pointes
Body system: Abnormality of the cardiovascular system

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13 genes linked to Torsade de pointes

Changes in these genes cause rare conditions in which Torsade de pointes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
HCN4hyperpolarization activated cyclic nucleotide gated potassium channel 4	Always	In 1 condition
SCN5Asodium voltage-gated channel alpha subunit 5	Always	In 1 condition
KCNE1potassium voltage-gated channel subfamily E regulatory subunit 1	Often (30–79%)	In 3 conditions
KCNE2potassium voltage-gated channel subfamily E regulatory subunit 2	Often (30–79%)	In 1 condition
KCNQ1potassium voltage-gated channel subfamily Q member 1	Often (30–79%)	In 3 conditions
KCNJ2potassium inwardly rectifying channel subfamily J member 2	Sometimes (5–29%)	In 1 condition
KCNJ5potassium inwardly rectifying channel subfamily J member 5	Sometimes (5–29%)	In 2 conditions
TANGO2transport and golgi organization 2 homolog	Sometimes (5–29%)	In 1 condition
RYR2ryanodine receptor 2	Rarely (1–4%)	In 1 condition
ALG10BALG10 alpha-1,2-glucosyltransferase B	Not recorded	In 1 condition
KCNH2potassium voltage-gated channel subfamily H member 2	Not recorded	In 1 condition
NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit	Not recorded	In 1 condition
SNTA1syntrophin alpha 1	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Ventricular arrhythmia

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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