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Trait

Irregular ankle bone maturation

Clinical name: Irregular tarsal ossification

Defective ossification in an irregular pattern of the seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.

HPO HP:0008134

Summary

Also called
Irregular tarsal centers, Irregular tarsal centres
Body system
Abnormality of limbsAbnormality of the musculoskeletal system

1 gene linked to Irregular ankle bone maturation

Changes in these genes cause rare conditions in which Irregular ankle bone maturation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal maturation of ankle bones

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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