Traits

Traits linked to DZIP1L

DAZ interacting zinc finger protein 1 like

The Human Phenotype Ontology links 52 traits to DZIP1L, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Hepatic fibrosis	Very often (80–99%)
Periportal fibrosis	Very often (80–99%)
Abnormal intrahepatic bile duct morphology	Often (30–79%)
Biliary hyperplasia	Often (30–79%)
Enlarged vein in esophagus	Often (30–79%)
Excessive buildup of connective tissue and scarring of liver at birth	Often (30–79%)
Fat malabsorption	Often (30–79%)
Feeding difficulties	Often (30–79%)
Slowed or blocked flow of bile from liver	Often (30–79%)
Accumulation of fluid in the abdomen	Sometimes (5–29%)
Bile duct inflammation	Sometimes (5–29%)
Hepatoblastoma	Sometimes (5–29%)
Jaundice	Sometimes (5–29%)
Protein-losing enteropathy	Sometimes (5–29%)
Bile duct cancer	Rarely (1–4%)
Pancreatic cysts	Rarely (1–4%)

Abnormality of the genitourinary system

Trait	How often it is seen
Hyperechogenic kidneys	Always
Enlarged kidney	Very often (80–99%)
Polycystic kidney dysplasia	Very often (80–99%)
Reduced renal corticomedullary differentiation	Often (30–79%)
Renal failure	Often (30–79%)
Stage 5 chronic kidney disease	Often (30–79%)
Acute kidney injury	Sometimes (5–29%)
Frequent urinary tract infections	Sometimes (5–29%)
Oliguria	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Decreased circulating vitamin K concentration	Often (30–79%)
Deficient in vitamin D	Often (30–79%)
Elevated gamma-glutamyltransferase level	Often (30–79%)
Increased serum bile acid concentration	Often (30–79%)
Low blood sodium levels	Often (30–79%)
Vitamin A deficiency	Often (30–79%)
Vitamin E deficiency	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Very often (80–99%)
Hypersplenism	Often (30–79%)
Increased spleen size	Often (30–79%)
Portal hypertension	Often (30–79%)
Enlarged liver and spleen	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Poorly developed lungs	Often (30–79%)
Respiratory failure	Often (30–79%)
Slow breathing	Sometimes (5–29%)
Spontaneous collapsed lung	Rarely (1–4%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Gastrointestinal bleeding	Sometimes (5–29%)
Low platelet count	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Flat nose	Rarely (1–4%)
Little lower jaw	Rarely (1–4%)

Abnormality of the nervous system

Trait	How often it is seen
Extreme thirst	Sometimes (5–29%)
Cognitive impairment	Rarely (1–4%)

Abnormality of limbs

Trait	How often it is seen
Abnormality of limbs	Rarely (1–4%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Low levels of amniotic fluid	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Rarely (1–4%)

Abnormality of the immune system

Trait	How often it is seen
Recurrent pneumonia	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Growth delay	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DZIP1L and how often each is seen. Find out more at hpo.jax.org.

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