Trait

Bifid epiglottis

A midline anterior-posterior cleft of the epiglottis that involves at least two-thirds of the epiglottic leaf. It is a useful feature for clinical diagnosis because it appears to be very rare in syndromes other than Pallister-Hall-Syndrome and is also rare as an isolated malformation.

HPO HP:0010564

Body system: Abnormality of the respiratory system

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10 condition reports read genes linked to this trait

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7 genes linked to Bifid epiglottis

Changes in these genes cause rare conditions in which Bifid epiglottis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
GLI3GLI family zinc finger 3	Often (30–79%)	In 2 conditions
DYNC2H1dynein cytoplasmic 2 heavy chain 1	Sometimes (5–29%)	In 1 condition
DYNC2I1dynein 2 intermediate chain 1	Sometimes (5–29%)	In 1 condition
DYNC2I2dynein 2 intermediate chain 2	Sometimes (5–29%)	In 1 condition
FOXE1forkhead box E1	Sometimes (5–29%)	In 1 condition
IFT80intraflagellar transport 80	Sometimes (5–29%)	In 1 condition
WDR35WD repeat domain 35	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal epiglottis morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.19-9814e911.

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