Traits

Traits linked to DNAJC13

DnaJ heat shock protein family (Hsp40) member C13

The Human Phenotype Ontology links 34 traits to DNAJC13, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Parkinsonism	Always
Akinesia	Often (30–79%)
Parkinsonism with favorable response to dopaminergic medication	Often (30–79%)
Resting tremor	Often (30–79%)
Agitation	Sometimes (5–29%)
Balance impairment	Sometimes (5–29%)
Decrease in size of the outer layer of the brain due to loss of brain cells	Sometimes (5–29%)
Depression	Sometimes (5–29%)
Difficulty sleeping	Sometimes (5–29%)
Disorder of involuntary muscle movements	Sometimes (5–29%)
Dystonia	Sometimes (5–29%)
Gliosis	Sometimes (5–29%)
Impulsivity	Sometimes (5–29%)
Lack of feeling, emotion, interest	Sometimes (5–29%)
Lewy bodies	Sometimes (5–29%)
Low frustration tolerance	Sometimes (5–29%)
Mental deterioration	Sometimes (5–29%)
Monotonic speech	Sometimes (5–29%)
Shuffled walk	Sometimes (5–29%)
Slow movements	Sometimes (5–29%)
Visual hallucinations	Sometimes (5–29%)
Dementia	Rarely (1–4%)
Schizophrenia	Rarely (1–4%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Frequent falls	Often (30–79%)
Muscle spasm	Sometimes (5–29%)
Rigidity	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Hyposmia	Often (30–79%)
Decreased facial expressions	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Chronic constipation	Often (30–79%)
Poor swallowing	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Orthostatic hypotension due to autonomic dysfunction	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Double vision	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Spastic/hyperactive bladder	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Weight loss	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DNAJC13 and how often each is seen. Find out more at hpo.jax.org.

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