Traits

Traits linked to IL2RA

interleukin 2 receptor subunit alpha

The Human Phenotype Ontology links 80 traits to IL2RA, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the immune system

Trait	Hvor ofte det ses
Decreased specific anti-polysaccharide antibody concentration	Altid
Eczema	Altid
Psoriasiform dermatitis	Altid
Recurrent bacterial infections	Altid
Recurrent fungal infections	Altid
Recurrent respiratory infections	Altid
Recurrent viral infections	Altid
Red scaly skin caused by inflammatory skin disease	Altid
Severe varicella zoster infection	Altid
Antinuclear antibody positivity	Meget ofte (80–99 %)
Abnormal circulating interleukin concentration	Ofte (30–79 %)
Autoimmunity	Ofte (30–79 %)
Increased circulating interferon-gamma concentration	Ofte (30–79 %)
Decreased immune function	Ikke registreret

Abnormality of the musculoskeletal system

Trait	Hvor ofte det ses
Bacterial infection of skin	Altid
Arthritis	Meget ofte (80–99 %)
Oligoarthritis	Meget ofte (80–99 %)
Double-Jointed	Ofte (30–79 %)
Enthesitis	Ofte (30–79 %)
Joint stiffness	Ofte (30–79 %)
Synovial lining hyperplasia	Ofte (30–79 %)
Synovitis	Ofte (30–79 %)
Abnormal cervical spine	Nogle gange (5–29 %)
Abnormality of the shoulder	Nogle gange (5–29 %)
Flexed joint that cannot be straightened	Nogle gange (5–29 %)
Hip osteoarthritis	Nogle gange (5–29 %)
Rheumatoid arthritis	Nogle gange (5–29 %)

Abnormality of limbs

Trait	Hvor ofte det ses
Abnormality of the ankle	Ofte (30–79 %)
Abnormality of the wrist	Ofte (30–79 %)
Ankle swelling	Ofte (30–79 %)
Knee osteoarthritis	Ofte (30–79 %)
Abnormality of the hand	Nogle gange (5–29 %)
Abnormality of the hip joint	Nogle gange (5–29 %)
Abnormality of the knuckle	Nogle gange (5–29 %)
Abnormality of the long bone of foot	Nogle gange (5–29 %)

Abnormality of the eye

Trait	Hvor ofte det ses
Uveitis	Ofte (30–79 %)
Anterior chamber synechiae	Nogle gange (5–29 %)
Band keratopathy	Nogle gange (5–29 %)
Decreased clarity of vision	Nogle gange (5–29 %)
Visual loss	Nogle gange (5–29 %)
Clouding of the lens of the eye	Sjældent (1–4%)
Glaucoma	Sjældent (1–4%)
Iridocyclitis	Sjældent (1–4%)

Abnormality of blood and blood-forming tissues

Trait	Hvor ofte det ses
Decreased regulatory T cell proportion	Altid
Hemolytic anemia	Altid
Inverted CD4:CD8 ratio	Altid
Low B cell count	Altid
Low T cell count	Altid
Low number of red blood cells or hemoglobin	Nogle gange (5–29 %)

Growth abnormality

Trait	Hvor ofte det ses
Faltering weight in infancy	Altid
Faltering weight	Ofte (30–79 %)
Mild growth deficiency	Nogle gange (5–29 %)
Severe growth delay in children	Nogle gange (5–29 %)
Weight loss	Nogle gange (5–29 %)

Laboratory abnormality

Trait	Hvor ofte det ses
Type 1 diabetes	Altid
High ESR	Ofte (30–79 %)
Joint swelling	Ofte (30–79 %)
Low-grade fever	Nogle gange (5–29 %)
Diabetes mellitus	Ikke registreret

Abnormality of head or neck

Trait	Hvor ofte det ses
Boxer's nasal deformity	Altid
Chronic oral thrush	Altid
Prominent forehead	Altid
Abnormality of the jaw joint	Nogle gange (5–29 %)

Abnormal cellular phenotype

Trait	Hvor ofte det ses
Decreased anti-CD3/28-induced T-cell proliferation	Altid
Decreased circulating IgA concentration	Altid
Increased circulating IgE concentration	Altid

Abnormality of the cardiovascular system

Trait	Hvor ofte det ses
Enlarged liver and spleen	Altid
Enlarged tonsils	Altid
Swollen lymph nodes	Altid

Abnormality of the integument

Trait	Hvor ofte det ses
Alopecia universalis	Altid
Patchy baldness	Altid
Scaling skin	Altid

Abnormality of the digestive system

Trait	Hvor ofte det ses
Chronic diarrhea	Altid
Villous atrophy	Altid

Abnormality of the endocrine system

Trait	Hvor ofte det ses
Thyroid gland inflammation	Altid
Underactive thyroid	Altid

Abnormality of the respiratory system

Trait	Hvor ofte det ses
Lung infiltrates	Altid
Pulmonary interstitial lymphocyte infiltration	Altid

Constitutional symptom

Trait	Hvor ofte det ses
Joint pain	Ofte (30–79 %)
Muscle ache	Nogle gange (5–29 %)

Hvor hyppigt det ses hos personer med en af genets tilstande, den hyppigste værdi på tværs af dem, sådan som Human Phenotype Ontology registrerer det. Disse sider beskriver egenskaber og den forskning, der ligger bag dem. De er ikke en diagnose, og hvis du har spørgsmål om symptomer, bør du spørge en læge eller genetisk rådgiver.

Hvor oplysningerne kommer fra

The Human Phenotype Ontology, release 2026-09-01: the traits linked to IL2RA and how often each is seen. Find out more at hpo.jax.org.

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