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Trait

Midline facial cleft

A congenital malformation with a cleft (gap or opening) in the midline of the face.

HPO HP:0100629

Summary

Body system
Abnormality of head or neck

2 genes linked to Midline facial cleft

Changes in these genes cause rare conditions in which Midline facial cleft is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ZSWIM6zinc finger SWIM-type containing 6AlwaysIn 1 condition
TBC1D32TBC1 domain family member 32Sometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Cleft of the face

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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