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Gene

DNAJB11

DnaJ heat shock protein family (Hsp40) member B11

Summary

Cytogenetic location
3q27.3
Coordinates
Chromosome 3: 186,570,720–186,585,793 (GRCh38)
Exons
10 exons across 15.1 kb
Protein
358 amino acids
Also known as
EDJ, HEDJ, ERdj3
MANE Select transcript
ENST00000265028.8NM_016306.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Polycystic Kidney Disease

    • A usually autosomal dominant and less frequently autosomal recessive genetic disorder characterized by the presence of numerous cysts in the kidneys leading to end-stage renal failure. The autosomal dominant trait is associated with abnormalities on the short arm of chromosome 16. Symptoms in patients with the autosomal dominant trait usually appear at middle age and include abdominal pain, hematuria, and high blood pressure. Patients may develop brain aneurysms and liver cysts. Patients with the autosomal recessive trait present with progressive renal failure early in life and symptoms resulting from hepatic fibrosis. The autosomal recessive trait is associated with abnormalities of chromosome 6. Polycystic kidney disease may also result as a side effect in patients on renal dialysis.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Tolvaptan (Jynarque, FDA 2018) for rapidly progressive ADPKD; blood pressure control (target <110/75); pain management; cyst infection treatment; brain MRA screening for intracranial aneurysms; kidney transplantation for ESRD

How DNAJB11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 3, with a bracket where DNAJB11 sits. DNAJB11 and 13 genes near it on chromosome 3, from 186,078,257 to 187,078,256.Chromosome 33q27.3p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29186.2 Mb186.4 Mb186.6 Mb186.8 Mb187 MbETV5: 186,045,536–186,110,318, reverse strandETV5DGKG: 186,105,668–186,362,326, reverse strandDGKGCRYGS: 186,536,578–186,546,702, reverse strandCRYGSTBCCD1: 186,546,024–186,570,543, reverse strandTBCCD1DNAJB11: 186,570,720–186,585,793, forward strandDNAJB11: 186,581,995–186,597,103, forward strandAHSG: 186,612,776–186,627,803, forward strandAHSGFETUB: 186,634,558–186,654,352, forward strandFETUBHRG: 186,660,216–186,678,452, forward strandHRGKNG1: 186,717,329–186,744,736, forward strandKNG1EIF4A2: 186,783,205–186,789,901, forward strandEIF4A2RFC4: 186,789,866–186,807,058, reverse strandRFC4ADIPOQ: 186,842,674–186,858,463, forward strandADIPOQST6GAL1: 186,930,325–187,078,932, forward strandST6GAL1Diagram of DNAJB11: 10 exons on the forward strand of chromosome 3Exon 1: 1 known disease-causing siteExon 2: 4 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 5: 5 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 1: 186,570,720–186,570,965, 246 basesExon 2: 186,572,095–186,572,251, 157 basesExon 3: 186,575,840–186,575,937, 98 basesExon 4: 186,577,668–186,577,800, 133 basesExon 5: 186,581,371–186,581,513, 143 basesExon 6: 186,581,995–186,582,077, 83 basesExon 7: 186,582,716–186,582,773, 58 basesExon 8: 186,583,865–186,583,976, 112 basesExon 9: 186,584,430–186,584,589, 160 basesExon 10: 186,585,344–186,585,793, 450 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 15.1 kb; 1,077 of those bases code for the protein.

How a genome test reads DNAJB11

24

positions in DNAJB11 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 15.1 kb of DNAJB11, introns included, not only the 1.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DNAJB11 gene: DnaJ heat shock protein family (Hsp40) member B11. Retrieved 16 October 2026, from https://dantelabs.com/genes/dnajb11

Vancouver

Dante Labs. DNAJB11 gene: DnaJ heat shock protein family (Hsp40) member B11 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dnajb11

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