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Gene

APOA4

apolipoprotein A4

Summary

Cytogenetic location
11q23.3
Coordinates
Chromosome 11: 116,820,700–116,823,304 (GRCh38)
Exons
3 exons across 2.6 kb
Protein
396 amino acids
MANE Select transcript
ENST00000357780.5NM_000482.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Hereditary Amyloidosis

    • Autosomal dominant

      Hereditary amyloidosis refers to a group of inherited conditions that make up one of the subtypes of amyloidosis. Hereditary amyloidosisis characterized by the deposit of an abnormal protein called amyloid in multiple organs of the body where it should not be, which causes disruption of organ tissue structure and function. In hereditary amyloidosis, amyloid deposits most often occur in tissues of the heart, kidneys, and nervous system. While symptoms of hereditary amyloidosis may appear in childhood, most individuals do not experience symptoms until adulthood. There are many types of hereditary amyloidosis associated with different gene mutations and abnormal proteins. The most common type of hereditary amyloidosis is transthyretin amyloidosis (ATTR), a condition in which the amyloid deposits are most often made up of the transthyretin protein which is made in the liver. Other examplesof hereditary amyloidosis include, but are not limited to, apolipoprotein AI amyloidosis (A ApoAI), gelsolin amyloidosis (A Gel), lysozyme amyloidosis (A Lys), cystatin C amyloidosis (A Cys), fibrinogen Aα-chain amyloidosis (A Fib), and apolipoprotein AII amyloidosis (A ApoAII).

      • 1 GenCC submitter rates it definitive or strong
      Actionability

      Tafamidis (kinetic stabilizer), patisiran (RNAi), vutrisiran (RNAi), inotersen (antisense), liver transplantation

How APOA4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 11, with a bracket where APOA4 sits. APOA4 and 13 genes near it on chromosome 11, from 116,322,002 to 117,322,001.Chromosome 1111q23.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25116.4 Mb116.6 Mb116.8 Mb117 Mb117.2 MbBUD13: 116,748,170–116,773,039, reverse strandBUD13ZPR1: 116,773,799–116,788,477, reverse strandZPR1APOA5: 116,789,014–116,793,026, reverse strandAPOA5APOA4: 116,820,700–116,823,304, reverse strandAPOA4APOC3: 116,827,019–116,835,254, forward strandAPOC3APOA1: 116,834,677–116,842,065, reverse strandAPOA1SIK3: 116,843,402–117,098,463, reverse strandSIK3PAFAH1B2: 117,144,278–117,176,894, forward strandPAFAH1B2SIDT2: 117,178,730–117,197,452, forward strandSIDT2TAGLN: 117,197,509–117,207,464, forward strandTAGLNPCSK7: 117,202,588–117,232,628, reverse strandPCSK7RNF214: 117,232,154–117,287,429, forward strandRNF214BACE1: 117,285,232–117,316,291, reverse strandBACE1CEP164: 117,314,557–117,413,616, forward strandCEP164Diagram of APOA4: 3 exons on the reverse strand of chromosome 11Exon 3: 116,820,700–116,821,881, 1,182 basesExon 2: 116,822,659–116,822,785, 127 basesExon 1: 116,823,143–116,823,304, 162 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.5 kb of the gene's 2.6 kb; 1,191 of those bases code for the protein.

Sequencing APOA4

4Low

How hard APOA4 is to sequence with short reads, out of 100

  • Mappability0%
  • Homology0%
  • Repeats4.4%
  • GC content38%
  • Reference coverage0%

Genes linked to the same conditions

Traits linked to APOA4

The Human Phenotype Ontology lists these as features of the rare conditions APOA4 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). APOA4 gene: apolipoprotein A4. Retrieved 18 October 2026, from https://dantelabs.com/genes/apoa4

Vancouver

Dante Labs. APOA4 gene: apolipoprotein A4 [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/apoa4

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