Trait
Narrowing and hardening of arteries
Clinical name: Atherosclerosis
A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls of medium-sized and large arteries and can lead to arterial stenosis with reduced or blocked blood flow.
Summary
- Also called
- Plaque build-up in arteries, Atherosclerotic cardiovascular disease
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test20 genes linked to Narrowing and hardening of arteries
Changes in these genes cause rare conditions in which Narrowing and hardening of arteries is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCA1ATP binding cassette subfamily A member 1 | Very often (80–99%) | In 2 conditions |
| APOA1apolipoprotein A1 | Very often (80–99%) | In 1 condition |
| ANGPTL6angiopoietin like 6 | Often (30–79%) | In 1 condition |
| COL3A1collagen type III alpha 1 chain | Often (30–79%) | In 1 condition |
| ENGendoglin | Often (30–79%) | In 1 condition |
| GGCXgamma-glutamyl carboxylase | Often (30–79%) | In 3 conditions |
| LMNAlamin A/C | Often (30–79%) | In 4 conditions |
| PPARGperoxisome proliferator activated receptor gamma | Often (30–79%) | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Often (30–79%) | In 1 condition |
| TGFBR3transforming growth factor beta receptor 3 | Often (30–79%) | In 1 condition |
| THSD1thrombospondin type 1 domain containing 1 | Often (30–79%) | In 1 condition |
| WRNWRN RecQ like helicase | Often (30–79%) | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Often (30–79%) | In 1 condition |
| ANTXR1ANTXR cell adhesion molecule 1 | Sometimes (5–29%) | In 1 condition |
| HGDhomogentisate 1,2-dioxygenase | Sometimes (5–29%) | In 1 condition |
| LCATlecithin-cholesterol acyltransferase | Sometimes (5–29%) | In 1 condition |
| VKORC1vitamin K epoxide reductase complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| AGXTalanine--glyoxylate aminotransferase | Rarely (1–4%) | In 1 condition |
| ALMS1ALMS1 centrosome and basal body associated protein | Not recorded | In 1 condition |
| LDLRAP1low density lipoprotein receptor adaptor protein 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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