Mitocondrial
Perda auditiva causada por antibióticos aminoglicosídeos em pessoas que têm variantes no gene mitocondrial MT-RNR1, como m.1555A>G, m.1494C>T ou m.1095T>C, que são transmitidas pela linha materna.
O que muda com um diagnóstico
As orientações clínicas (CPIC) aconselham a evitar os aminoglicosídeos em portadores, a menos que uma infeção seja potencialmente fatal e não exista alternativa segura; os familiares por linha materna também podem ser portadores da variante.
Também conhecida como
aminoglycoside-induced hearing loss; deafness, mitochondrial, modifier of, mitochondrial; deafness, streptomycin-induced; mitochondrial isolated neurosensory deafness with susceptibility to aminoglycoside exposure; mitochondrial isolated neurosensory hearing loss with susceptibility to aminoglycoside exposure; mitochondrial isolated sensorineural deafness with susceptibility to aminoglycoside exposure; mitochondrial isolated sensorineural hearing loss with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic neurosensory deafness with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic neurosensory hearing loss with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic sensorineural hearing loss with susceptibility to aminoglycoside exposure; streptomycin ototoxicity
