Mitokondriális
Hearing loss caused by aminoglycoside antibiotics in people carrying variants in the mitochondrial MT-RNR1 gene, such as m.1555A>G, m.1494C>T or m.1095T>C, which are passed down the maternal line.
Mit változtat a diagnózis
Clinical guidelines (CPIC) advise avoiding aminoglycosides in carriers unless an infection is life-threatening and there is no safe alternative; maternal relatives may also carry the variant.
Más néven
deafness, mitochondrial, modifier of, mitochondrial; deafness, streptomycin-induced; mitochondrial isolated neurosensory deafness with susceptibility to aminoglycoside exposure; mitochondrial isolated neurosensory hearing loss with susceptibility to aminoglycoside exposure; mitochondrial isolated sensorineural deafness with susceptibility to aminoglycoside exposure; mitochondrial isolated sensorineural hearing loss with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic neurosensory deafness with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic neurosensory hearing loss with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic sensorineural hearing loss with susceptibility to aminoglycoside exposure; streptomycin ototoxicity
