Mitokondriel
Høretab forårsaget af aminoglykosidantibiotika hos personer, der bærer varianter i det mitokondrielle gen MT-RNR1, såsom m.1555A>G, m.1494C>T eller m.1095T>C, som nedarves via moderens linje.
Hvad en diagnose ændrer
Kliniske retningslinjer (CPIC) anbefaler at undgå aminoglykosider hos bærere, medmindre en infektion er livstruende, og der ikke findes et sikkert alternativ; moderens slægtninge kan også bære varianten.
Også kendt som
aminoglycoside-induced hearing loss; deafness, mitochondrial, modifier of, mitochondrial; deafness, streptomycin-induced; mitochondrial isolated neurosensory deafness with susceptibility to aminoglycoside exposure; mitochondrial isolated neurosensory hearing loss with susceptibility to aminoglycoside exposure; mitochondrial isolated sensorineural deafness with susceptibility to aminoglycoside exposure; mitochondrial isolated sensorineural hearing loss with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic neurosensory deafness with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic neurosensory hearing loss with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic sensorineural hearing loss with susceptibility to aminoglycoside exposure; streptomycin ototoxicity
