Mitokondriell
Hørselstap forårsaket av aminoglykosidantibiotika hos personer som bærer varianter i det mitokondrielle genet MT-RNR1, som m.1555A>G, m.1494C>T eller m.1095T>C. Disse arves nedover i morslinjen.
Hva en diagnose endrer
Kliniske retningslinjer (CPIC) anbefaler at bærere unngår aminoglykosider med mindre infeksjonen er livstruende og det ikke finnes noe trygt alternativ. Slektninger i morslinjen kan også bære varianten.
Også kjent som
aminoglycoside-induced hearing loss; deafness, mitochondrial, modifier of, mitochondrial; deafness, streptomycin-induced; mitochondrial isolated neurosensory deafness with susceptibility to aminoglycoside exposure; mitochondrial isolated neurosensory hearing loss with susceptibility to aminoglycoside exposure; mitochondrial isolated sensorineural deafness with susceptibility to aminoglycoside exposure; mitochondrial isolated sensorineural hearing loss with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic neurosensory deafness with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic neurosensory hearing loss with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposure; mitochondrial non-syndromic sensorineural hearing loss with susceptibility to aminoglycoside exposure; streptomycin ototoxicity
