Trait

Thickened, discolored skin under nail

Clinical name: Subungual hyperkeratosis

A thickening of the stratum corneum in the region beneath the nails.

HPO HP:0008392

Also called: Thickened, discoloured skin under nail
Body system: Abnormality of the integument

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8 genes linked to Thickened, discolored skin under nail

Changes in these genes cause rare conditions in which Thickened, discolored skin under nail is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
JUPjunction plakoglobin	Always	In 1 condition
CARD14caspase recruitment domain family member 14	Often (30–79%)	In 2 conditions
KDF1keratinocyte differentiation factor 1	Often (30–79%)	In 1 condition
KRT14keratin 14	Often (30–79%)	In 1 condition
MBTPS2membrane bound transcription factor peptidase, site 2	Sometimes (5–29%)	In 2 conditions
KRT17keratin 17	Not recorded	In 1 condition
KRT6Bkeratin 6B	Not recorded	In 1 condition
TRPV3transient receptor potential cation channel subfamily V member 3	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal subungual morphology Hyperkeratosis

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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