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Gene

CNNM2

cyclin and CBS domain divalent metal cation transport mediator 2

Summary

Cytogenetic location
10q24.32
Coordinates
Chromosome 10: 102,918,294–103,090,222 (GRCh38)
Exons
8 exons across 171.9 kb
Protein
875 amino acids
Also known as
SLC70A2
Previous symbols
ACDP2
MANE Select transcript
ENST00000369878.9NM_017649.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Familial Hypomagnesemia

    • Familial Primary Hypomagnesemia

      A group of inherited magnesium-wasting disorders caused by variants in genes such as CLDN16, CLDN19, TRPM6, CNNM2 and FXYD2; the CLDN16 and CLDN19 forms can progress to chronic kidney disease.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Magnesium supplementation can control symptoms, and some forms need kidney function and eye monitoring.

How CNNM2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where CNNM2 sits. CNNM2 and 20 genes near it on chromosome 10, from 102,504,258 to 103,504,257.Chromosome 1010q24.32p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.3102.6 Mb102.8 Mb103 Mb103.2 Mb103.4 MbSUFU: 102,503,952–102,633,535, forward strandSUFUTRIM8: 102,642,394–102,662,789, forward strandTRIM8ARL3: 102,673,731–102,714,527, reverse strandARL3SFXN2: 102,714,476–102,743,492, forward strandSFXN2WBP1L: 102,743,923–102,834,613, forward strandWBP1LCYP17A1: 102,830,460–102,837,506, reverse strandCYP17A1BORCS7: 102,854,224–102,864,979, forward strandBORCS7BORCS7-ASMT: 102,854,272–102,901,899, forward strandBORCS7-ASMTAS3MT: 102,869,296–102,901,911, forward strandAS3MTCNNM2: 102,918,294–103,090,222, forward strandCNNM2NT5C2: 103,086,478–103,277,622, reverse strandNT5C2RPEL1: 103,245,887–103,248,016, forward strandRPEL1INA: 103,277,082–103,290,351, forward strandINAPCGF6: 103,302,796–103,351,150, reverse strandPCGF6TAF5: 103,367,948–103,389,323, forward strandTAF5ATP5MK: 103,388,974–103,396,492, reverse strandATP5MKPDCD11: 103,396,602–103,446,297, forward strandPDCD11CALHM2: 103,446,777–103,452,780, reverse strandCALHM2CALHM1: 103,453,240–103,458,900, reverse strandCALHM1CALHM3: 103,472,804–103,479,240, reverse strandCALHM3NEURL1: 103,493,592–103,595,168, forward strandNEURL1Diagram of CNNM2: 8 exons on the forward strand of chromosome 10Exon 1: 16 known disease-causing sitesExon 2: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 7: 1 known disease-causing siteExon 1: 102,918,294–102,920,101, 1,808 basesExon 2: 103,049,707–103,049,850, 144 basesExon 3: 103,054,329–103,054,466, 138 basesExon 4: 103,056,795–103,056,964, 170 basesExon 5: 103,068,629–103,068,722, 94 basesExon 6: 103,071,774–103,071,839, 66 basesExon 7: 103,076,086–103,076,270, 185 basesExon 8: 103,076,971–103,090,222, 13,252 bases124685′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 15.9 kb of the gene's 171.9 kb; 2,628 of those bases code for the protein.

How a genome test reads CNNM2

20

positions in CNNM2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 171.9 kb of CNNM2, introns included, not only the 15.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CNNM2 gene: cyclin and CBS domain divalent metal cation transport mediator 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/cnnm2

Vancouver

Dante Labs. CNNM2 gene: cyclin and CBS domain divalent metal cation transport mediator 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cnnm2

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