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Trait

Angioid streaks

Irregular lines in the outer retina and Bruch membrane that are typically configured in a radiating fashion and emanate from the optic disc. Angioid streaks are crack-like dehiscences in abnormally thickened and calcified Bruch membrane, resulting in atrophy of the overlying retinal pigment epithelium. They may be associated with a number of endocrine, metabolic, and connective tissue abnormalities but can be idiopathic. They can be associated with neovascular complexes (choroid).

HPO HP:0001102

Summary

Also called
Angioid streaks of the fundus, Angioid streaks of the retina, Angioid streaks, retina, Knapp streaks, Laquer cracks of the retina
Body system
Abnormality of the eye

11 condition reports read genes linked to this trait

Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.

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10 genes linked to Angioid streaks

Changes in these genes cause rare conditions in which Angioid streaks is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ABCC6ATP binding cassette subfamily C member 6Very often (80–99%)In 4 conditions
ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1Very often (80–99%)In 2 conditions
XYLT1xylosyltransferase 1Very often (80–99%)In 1 condition
XYLT2xylosyltransferase 2Very often (80–99%)In 1 condition
GGCXgamma-glutamyl carboxylaseOften (30–79%)In 3 conditions
VKORC1vitamin K epoxide reductase complex subunit 1Sometimes (5–29%)In 1 condition
GALNT3polypeptide N-acetylgalactosaminyltransferase 3Not recordedIn 1 condition
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaNot recordedIn 1 condition
PTENphosphatase and tensin homologNot recordedIn 1 condition
TNFRSF11BTNF receptor superfamily member 11bNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Retina issue

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.19-9814e911.

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