Traits

Traits linked to TFG

trafficking from ER to golgi regulator

The Human Phenotype Ontology links 64 traits to TFG, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Abnormality of peripheral nerve conduction	Always
Babinski sign	Always
Delayed ability to walk	Always
Demyelinating motor neuropathy	Always
Increased reflexes	Always
Loss of ability to walk	Always
Abnormal myelination	Very often (80–99%)
Abnormal peripheral action potential amplitude	Very often (80–99%)
Absent reflexes	Very often (80–99%)
Inability to walk	Very often (80–99%)
Motor polyneuropathy	Very often (80–99%)
Nerve damage causing decreased feeling and movement	Very often (80–99%)
Peripheral neuropathy	Very often (80–99%)
Somatic sensory dysfunction	Very often (80–99%)
Abnormal cranial nerve physiology	Often (30–79%)
Bulbar signs	Often (30–79%)
Decreased sensation in extremities	Often (30–79%)
Tremor	Often (30–79%)
Twitching	Often (30–79%)
Abnormal seventh cranial physiology	Sometimes (5–29%)
Hand tremor	Sometimes (5–29%)
Lower cranial nerve dysfunction	Sometimes (5–29%)
Abnormal gait	Not recorded
Axonal degeneration	Not recorded
Damage to nerves that sense feeling	Not recorded
Decreased number of peripheral myelinated nerve fibers	Not recorded
Degeneration of anterior horn cells	Not recorded
Gliosis	Not recorded
Muscle twitch	Not recorded
Paralysis of all four limbs	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Difficulty in standing	Always
Difficulty walking up stairs	Always
Lower limb amyotrophy	Always
Lower limb spasticity	Always
Muscle weakness	Always
Spastic paraplegia	Always
Distal lower limb amyotrophy	Very often (80–99%)
Fatiguable weakness of proximal limb muscles	Very often (80–99%)
Intermittent painful muscle spasms	Very often (80–99%)
Involuntary muscle stiffness, contraction, or spasm	Very often (80–99%)
EMG: positive sharp waves	Often (30–79%)
Muscle spasm	Not recorded
Proximal neurogenic muscle weakness	Not recorded
Wasting of muscles near the body	Not recorded

Abnormality of limbs

Trait	How often it is seen
Hand muscle degeneration	Always
Abnormality of the Achilles tendon	Very often (80–99%)
Decreased arm strength	Very often (80–99%)
Lower limb muscle weakness	Very often (80–99%)
Limb fasciculations	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Elevated blood creatine phosphokinase	Often (30–79%)
High blood sugar	Often (30–79%)
Abnormal glucose homeostasis	Sometimes (5–29%)
Elevated lipids in blood	Sometimes (5–29%)
Mildly elevated creatine kinase	Not recorded

Abnormality of the respiratory system

Trait	How often it is seen
Cough	Very often (80–99%)
Breathing difficulty	Sometimes (5–29%)
Respiratory failure	Sometimes (5–29%)
Respiratory failure requiring assisted ventilation	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Nasogastric tube feeding in infancy	Sometimes (5–29%)
Poor swallowing	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Optic atrophy	Always
Visual loss	Always

Abnormality of the genitourinary system

Trait	How often it is seen
Urinary tract abnormalities	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
Aspiration pneumonia	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TFG and how often each is seen. Find out more at hpo.jax.org.

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