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Gene

MYO15A

myosin XVA

Summary

Cytogenetic location
17p11.2
Coordinates
Chromosome 17: 18,108,756–18,179,800 (GRCh38)
Exons
66 exons across 71 kb
Protein
3,530 amino acids
Previous symbols
DFNB3, MYO15
MANE Select transcript
ENST00000647165.2NM_016239.4
Locus type
Protein-coding

Curated report relevant to this gene

    • Hearing Loss and Deafness

      • Nonsyndromic Genetic Hearing Loss

        One of 97 genes linked to it

        Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong
        Actionability

        Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.

    How MYO15A is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    • Variants with a page
    Chromosome 17, with a bracket where MYO15A sits. MYO15A and 17 genes near it on chromosome 17, from 17,644,278 to 18,644,277.Chromosome 1717p11.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.317.8 Mb18 Mb18.2 Mb18.4 Mb18.6 MbRAI1: 17,681,323–17,811,453, forward strandRAI1SREBF1: 17,810,399–17,837,035, reverse strandSREBF1TOM1L2: 17,843,507–17,972,470, reverse strandTOM1L2DRC3: 17,972,813–18,016,889, forward strandDRC3ATPAF2: 17,977,409–18,040,833, reverse strandATPAF2GID4: 18,039,371–18,068,405, forward strandGID4DRG2: 18,087,876–18,107,979, forward strandDRG2MYO15A: 18,108,756–18,179,800, forward strandMYO15AALKBH5: 18,183,034–18,209,954, forward strandALKBH5LLGL1: 18,225,542–18,244,876, forward strandLLGL1FLII: 18,244,782–18,260,420, reverse strandFLIIMIEF2: 18,259,527–18,266,552, forward strandMIEF2TOP3A: 18,271,428–18,315,025, reverse strandTOP3ASMCR8: 18,315,293–18,328,056, forward strandSMCR8SHMT1: 18,327,686–18,363,562, reverse strandSHMT1EVPLL: 18,377,674–18,389,652, forward strandEVPLLLGALS9C: 18,476,737–18,494,945, forward strandLGALS9CTBC1D28: 18,634,247–18,644,427, reverse strandTBC1D28Diagram of MYO15A: 66 exons on the forward strand of chromosome 17Exon 2: 90 known disease-causing sitesExon 3: 1 known disease-causing siteExon 4: 4 known disease-causing sitesExon 5: 6 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 9: 5 known disease-causing sitesExon 10: 4 known disease-causing sitesExon 11: 5 known disease-causing sitesExon 12: 6 known disease-causing sitesExon 13: 5 known disease-causing sitesExon 14: 1 known disease-causing siteExon 15: 4 known disease-causing sitesExon 16: 3 known disease-causing sitesExon 17: 5 known disease-causing sitesExon 18: 3 known disease-causing sitesExon 19: 2 known disease-causing sitesExon 20: 4 known disease-causing sitesExon 21: 2 known disease-causing sitesExon 22: 5 known disease-causing sitesExon 23: 4 known disease-causing sitesExon 24: 8 known disease-causing sitesExon 25: 5 known disease-causing sitesExon 27: 2 known disease-causing sitesExon 28: 2 known disease-causing sitesExon 29: 2 known disease-causing sitesExon 30: 17 known disease-causing sitesExon 31: 8 known disease-causing sitesExon 32: 2 known disease-causing sitesExon 33: 11 known disease-causing sitesExon 34: 3 known disease-causing sitesExon 35: 2 known disease-causing sitesExon 36: 5 known disease-causing sitesExon 38: 4 known disease-causing sitesExon 39: 1 known disease-causing siteExon 40: 3 known disease-causing sitesExon 41: 1 known disease-causing siteExon 42: 4 known disease-causing sitesExon 43: 6 known disease-causing sitesExon 44: 4 known disease-causing sitesExon 45: 6 known disease-causing sitesExon 46: 6 known disease-causing sitesExon 47: 7 known disease-causing sitesExon 48: 5 known disease-causing sitesExon 49: 6 known disease-causing sitesExon 50: 4 known disease-causing sitesExon 51: 7 known disease-causing sitesExon 52: 2 known disease-causing sitesExon 53: 1 known disease-causing siteExon 54: 5 known disease-causing sitesExon 56: 6 known disease-causing sitesExon 57: 5 known disease-causing sitesExon 58: 4 known disease-causing sitesExon 59: 1 known disease-causing siteExon 60: 3 known disease-causing sitesExon 61: 6 known disease-causing sitesExon 62: 3 known disease-causing sitesExon 63: 7 known disease-causing sitesExon 64: 6 known disease-causing sitesExon 65: 3 known disease-causing sitesExon 66: 3 known disease-causing sitesExon 1: 18,108,756–18,108,824, 69 basesExon 2: 18,118,582–18,122,409, 3,828 bases. 3 variants with a page in exon 2. List themExon 3: 18,124,483–18,124,565, 83 basesExon 4: 18,125,168–18,125,231, 64 basesExon 5: 18,126,347–18,126,456, 110 basesExon 6: 18,126,791–18,126,865, 75 basesExon 7: 18,127,075–18,127,165, 91 basesExon 8: 18,130,805–18,130,810, 6 basesExon 9: 18,131,239–18,131,342, 104 basesExon 10: 18,131,468–18,131,531, 64 bases. 2 variants with a page in exon 10. List themExon 11: 18,132,453–18,132,566, 114 basesExon 12: 18,133,225–18,133,386, 162 basesExon 13: 18,135,711–18,135,824, 114 basesExon 14: 18,136,417–18,136,475, 59 bases. 1 variant with a page in exon 14. List themExon 15: 18,136,563–18,136,686, 124 basesExon 16: 18,137,584–18,137,679, 96 basesExon 17: 18,138,115–18,138,246, 132 basesExon 18: 18,138,811–18,138,936, 126 basesExon 19: 18,139,534–18,139,611, 78 basesExon 20: 18,140,517–18,140,665, 149 basesExon 21: 18,140,787–18,140,832, 46 basesExon 22: 18,141,019–18,141,143, 125 basesExon 23: 18,141,653–18,141,770, 118 basesExon 24: 18,142,079–18,142,254, 176 basesExon 25: 18,142,756–18,142,840, 85 basesExon 26: 18,143,566–18,143,619, 54 basesExon 27: 18,143,715–18,143,796, 82 basesExon 28: 18,143,870–18,144,000, 131 basesExon 29: 18,144,497–18,144,592, 96 basesExon 30: 18,145,872–18,146,107, 236 bases. 1 variant with a page in exon 30. List themExon 31: 18,148,029–18,148,210, 182 basesExon 32: 18,148,496–18,148,568, 73 basesExon 33: 18,148,761–18,148,952, 192 basesExon 34: 18,149,216–18,149,376, 161 basesExon 35: 18,149,486–18,149,580, 95 basesExon 36: 18,150,429–18,150,543, 115 basesExon 37: 18,150,698–18,150,765, 68 basesExon 38: 18,150,836–18,150,913, 78 basesExon 39: 18,151,110–18,151,290, 181 basesExon 40: 18,151,395–18,151,527, 133 basesExon 41: 18,151,846–18,151,951, 106 basesExon 42: 18,152,112–18,152,184, 73 basesExon 43: 18,153,775–18,153,896, 122 basesExon 44: 18,154,131–18,154,190, 60 basesExon 45: 18,154,680–18,154,755, 76 basesExon 46: 18,155,110–18,155,225, 116 basesExon 47: 18,155,314–18,155,432, 119 basesExon 48: 18,156,195–18,156,336, 142 basesExon 49: 18,156,954–18,157,065, 112 basesExon 50: 18,157,156–18,157,230, 75 basesExon 51: 18,157,722–18,157,900, 179 basesExon 52: 18,158,523–18,158,638, 116 basesExon 53: 18,158,925–18,158,997, 73 basesExon 54: 18,159,275–18,159,347, 73 basesExon 55: 18,159,606–18,159,679, 74 basesExon 56: 18,159,935–18,160,017, 83 basesExon 57: 18,161,317–18,161,447, 131 basesExon 58: 18,162,585–18,162,679, 95 basesExon 59: 18,163,244–18,163,321, 78 basesExon 60: 18,163,742–18,163,838, 97 basesExon 61: 18,166,361–18,166,521, 161 basesExon 62: 18,167,590–18,167,723, 134 bases. 1 variant with a page in exon 62. List themExon 63: 18,171,638–18,171,771, 134 basesExon 64: 18,172,157–18,172,290, 134 basesExon 65: 18,173,781–18,173,921, 141 basesExon 66: 18,178,769–18,179,800, 1,032 bases15101520253035404550556065665′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 11.8 kb of the gene's 71 kb; 10,593 of those bases code for the protein.

    Sequencing MYO15A

    431

    positions in MYO15A where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 71 kb of MYO15A, introns included, not only the 11.8 kb of exons.

    Variants with a page (9)

    The MYO15A variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.

    VariantHGVS c.Exon or intronPosition (GRCh38)ClinVar classificationReview status
    A1548Tc.4642G>AExon 1418,136,462Likely pathogenic3 stars out of 4 reviewed by expert panel
    c.9517+2T>CIntron 5718,161,449Likely pathogenic3 stars out of 4 reviewed by expert panel
    I2113Fc.6337A>TExon 3018,145,935Likely pathogenic3 stars out of 4 reviewed by expert panel
    Q3349Xc.10045C>TExon 6218,167,686Pathogenic3 stars out of 4 reviewed by expert panel
    V1400Mc.4198G>AExon 1018,131,523Pathogenic3 stars out of 4 reviewed by expert panel
    Y332Xc.996C>GExon 218,119,796Pathogenic3 stars out of 4 reviewed by expert panel
    Y380Mfs*64c.1137delExon 218,119,933Likely pathogenic3 stars out of 4 reviewed by expert panel
    Y393Cfs*41c.1171_1177dupExon 218,119,970Pathogenic3 stars out of 4 reviewed by expert panel
    Y1392Xc.4176C>AExon 1018,131,501Pathogenic3 stars out of 4 reviewed by expert panel

    Genes linked to the same conditions

    Traits linked to MYO15A

    The Human Phenotype Ontology lists these as features of the rare conditions MYO15A can cause. Each trait's page lists the other genes linked to it.

    External links

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). MYO15A gene: myosin XVA. Retrieved 17 October 2026, from https://dantelabs.com/genes/myo15a

    Vancouver

    Dante Labs. MYO15A gene: myosin XVA [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/myo15a

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