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Gene

NOS3

nitric oxide synthase 3

Summary

Cytogenetic location
7q36.1
Coordinates
Chromosome 7: 150,991,017–151,014,588 (GRCh38)
Exons
27 exons across 23.6 kb
Protein
1,203 amino acids
Also known as
ECNOS, eNOS
MANE Select transcript
ENST00000297494.8NM_000603.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Trait report that reads NOS3

How NOS3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 7, with a bracket where NOS3 sits. NOS3 and 32 genes near it on chromosome 7, from 150,502,803 to 151,502,802.Chromosome 77q36.1p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3150.6 Mb150.8 Mb151 Mb151.2 Mb151.4 MbGIMAP7: 150,514,852–150,521,073, forward strandGIMAP7GIMAP4: 150,567,242–150,574,512, forward strandGIMAP4GIMAP6: 150,625,375–150,632,651, reverse strandGIMAP6GIMAP2: 150,685,647–150,694,763, forward strandGIMAP2GIMAP1: 150,716,606–150,724,284, forward strandGIMAP1GIMAP1-GIMAP5: 150,716,668–150,743,646, forward strandGIMAP1-GIMAP5GIMAP5: 150,722,253–150,750,033, forward strandGIMAP5TMEM176B: 150,789,455–150,823,877, reverse strandTMEM176BTMEM176A: 150,799,598–150,805,122, forward strandTMEM176AAOC1: 150,824,627–150,872,465, forward strandAOC1KCNH2: 150,944,064–150,978,394, reverse strandKCNH2NOS3: 150,991,017–151,014,588, forward strandNOS3ATG9B: 151,012,209–151,024,499, reverse strandATG9BABCB8: 151,028,422–151,047,782, forward strandABCB8ASIC3: 151,048,292–151,052,756, forward strandASIC3CDK5: 151,051,517–151,057,952, reverse strandCDK5SLC4A2: 151,057,210–151,076,527, forward strand: 151,061,928–151,061,978, forward strandFASTK: 151,076,585–151,080,881, reverse strandTMUB1: 151,081,082–151,083,533, reverse strandAGAP3: 151,085,831–151,144,450, forward strandAGAP3GBX1: 151,147,669–151,174,745, reverse strandGBX1ASB10: 151,175,684–151,187,832, reverse strandASB10DRC11L: 151,190,873–151,205,496, reverse strandDRC11LH2BK1: 151,207,416–151,210,488, reverse strandH2BK1ABCF2-H2BK1: 151,207,837–151,227,166, reverse strandABCF2: 151,211,484–151,227,264, reverse strandCHPF2: 151,232,483–151,240,979, forward strandSMARCD3: 151,238,764–151,277,896, reverse strandNUB1: 151,341,704–151,381,097, forward strandNUB1WDR86: 151,375,909–151,410,727, reverse strandWDR86CRYGN: 151,428,293–151,440,813, reverse strandCRYGNRHEB: 151,465,976–151,520,120, reverse strandRHEBDiagram of NOS3: 27 exons on the forward strand of chromosome 7Exon 1: 150,991,017–150,991,300, 284 basesExon 2: 150,993,753–150,993,961, 209 basesExon 3: 150,995,203–150,995,314, 112 basesExon 4: 150,996,404–150,996,552, 149 basesExon 5: 150,996,763–150,996,925, 163 basesExon 6: 150,998,357–150,998,448, 92 basesExon 7: 150,998,539–150,998,680, 142 basesExon 8: 150,998,946–150,999,085, 140 basesExon 9: 150,999,190–150,999,364, 175 basesExon 10: 151,000,498–151,000,599, 102 basesExon 11: 151,001,231–151,001,425, 195 basesExon 12: 151,001,544–151,001,617, 74 basesExon 13: 151,001,821–151,001,965, 145 basesExon 14: 151,002,200–151,002,304, 105 basesExon 15: 151,006,427–151,006,494, 68 basesExon 16: 151,006,889–151,007,005, 117 basesExon 17: 151,007,102–151,007,276, 175 basesExon 18: 151,008,930–151,009,062, 133 basesExon 19: 151,009,189–151,009,267, 79 basesExon 20: 151,009,398–151,009,585, 188 basesExon 21: 151,010,115–151,010,287, 173 basesExon 22: 151,010,597–151,010,807, 211 basesExon 23: 151,010,899–151,010,986, 88 basesExon 24: 151,012,351–151,012,472, 122 basesExon 25: 151,013,231–151,013,379, 149 basesExon 26: 151,013,724–151,013,918, 195 basesExon 27: 151,014,008–151,014,588, 581 bases1510152025275′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.4 kb of the gene's 23.6 kb; 3,612 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). NOS3 gene: nitric oxide synthase 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/nos3

Vancouver

Dante Labs. NOS3 gene: nitric oxide synthase 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/nos3

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